ArticleScientific reports2022
Evaluation of the inflammatory and osteogenic response induced by titanium particles released during implantoplasty of dental implants.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The trial behind it
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Who cites it
19 citing papers in PubMed.
- Repassivation of Titanium Surface with Different Disinfectants After Implantoplasty: Effects on Corrosion, Ion Release, Cytotoxicity and Bacterial Behaviour-An In Vitro Study.Dentistry journal · 2026Article
- Surface Modification of Titanium with EGCG and Hexamethylenediamine Coating for BMP‑2 Grafting: An Investigation of Osteogenic Properties.ACS omega · 2026Article
- A Redox Amplification Interface Linking Mitochondrial Dysfunction, Immune-Derived Oxidants, and Biomaterial Electrochemistry in Chronic Inflammation.International journal of molecular sciences · 2026Review
- Mechanical Fatigue of Titanium Dental Implants After Implantoplasty: An In Vitro Study Combined with Finite Element Simulations.Journal of functional biomaterials · 2026Article
- TRPV1-linked neuropeptide axes in periodontitis and peri-implantitis.Frontiers in endocrinology · 2026Review
- Immunological and tissue reactions to titanium particles generated by the mechanical decontamination of dental implants: In vitro and in vivo study.Medicina oral, patologia oral y cirugia bucal · 2026Article
- Release of Titanium Particles After Implantoplasty in the Treatment of Peri-Implantitis: Local and Systemic Implications-An Integrative Systematic Review.Journal of clinical medicine · 2025Review
- Synergistic exacerbation of periprosthetic osteolysis by inflammatory bowel disease and titanium ions: Impaired osteogenesis of BMSCs via PI3K/AKT signaling.Materials today. Bio · 2025Article
- Influence of Different Implantoplasty Designs on the Fatigue Resistance of Dental Implants: A Systematic Review.Journal of clinical medicine · 2025Review
- Titanium-Aluminum-Vanadium Surfaces Generated Using Sequential Nanosecond and Femtosecond Laser Etching Provide Osteogenic Nanotopography on Additively Manufactured Implants.Biomimetics (Basel, Switzerland) · 2025Article
- The Novel iMPACT Tool and Quadrant Protocol for Peri-Implantitis: Surface Refinement and Re-Osseointegration Validated by SEM/EDS and Long-Term Clinical Case Reports.Medicina (Kaunas, Lithuania) · 2025Article
- Evaluation of Titanium Particles, TNF-α, and Caspase-3 Concentrations in Patients with Bones Fixations of the Maxilla and Mandibule.International journal of molecular sciences · 2025Article
- Review
- Patient Centricity-An Empirical Research on Titanium Dental Implants and Their Adverse Effects on Health Condition.Healthcare (Basel, Switzerland) · 2024Article
- The Effect of Implantoplasty on the Fatigue Behavior and Corrosion Resistance in Titanium Dental Implants.Materials (Basel, Switzerland) · 2024Article
- Efficacy of a Solution Containing 33% Trichloroacetic Acid and Hydrogen Peroxide in Decontaminating Machined vs. Sand-Blasted Acid-Etched Titanium Surfaces.Journal of functional biomaterials · 2024Article
- In vitro evaluation of different protective techniques to reduce titanium particle contamination during implantoplasty.Clinical oral investigations · 2023Article
- Investigation of the Influence of Roughness and Dental Implant Design on Primary Stability via Analysis of Insertion Torque and Implant Stability Quotient: An In Vitro Study.Journal of clinical medicine · 2023Article
- Effects of Hypochlorous Acid and Hydrogen Peroxide Treatment on Bacterial Disinfection Treatments in Implantoplasty Procedures.Materials (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Implantoplasty is a mechanical decontamination technique that consists of removing the threads and polishing and smoothing the dental implant surface. During implantoplasty there is a large release of titanium metal particles that might provoke a proinflammatory response and reduce the viability of osteogenic cells. We analyze the inflammatory and osteogenic response induced by Ti6Al4V particles released during implantoplasty and by as-received commercially pure Ti particles. Macrophages stimulated with metal particles obtained by implantoplasty and with as-received Ti particles showed an increased proinflammatory expression of TNF-α and a decreased expression of TGF-β and CD206. Regarding cytokine release, there was an increase in IL-1β, while IL-10 decreased. The osteogenic response of Ti6Al4V extracts showed a significant decrease in Runx2 and OC expression compared to the controls and commercially pure Ti extracts. There were no relevant changes in ALP activity. Thus, implantoplasty releases metal particles that seems to induce a pro-inflammatory response and reduce the expression of osteogenic markers.
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