Evidence map›Paper›PMID 36138017›Full record

ArticleNature communications2022

Ubiquitination of CLIP-170 family protein restrains polarized growth upon DNA replication stress.

Xi Wang, Fan Zheng, Yuan-Yuan Yi, Gao-Yuan Wang, Li-Xin Hong, Dannel McCollum, Chuanhai Fu, Yamei Wang, Quan-Wen Jin

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 88% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Xi Wang *State Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, 361102, Fujian, China.ORCID 0000-0003-3894-5440
Fan Zheng *School of Life Sciences, University of Science and Technology of China, Hefei, 230026, Anhui, China.ORCID 0000-0001-7005-0941
Yuan-Yuan YiState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, 361102, Fujian, China.ORCID 0000-0001-8774-2047
Gao-Yuan WangState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, 361102, Fujian, China.ORCID 0000-0003-3165-0818
Li-Xin HongState Key Laboratory of Cellular Stress Biology, School of Medicine, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, 361102, Fujian, China.
Dannel McCollumDepartment of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, MA, 01605, USA.ORCID 0000-0003-0278-2715
Chuanhai FuSchool of Life Sciences, University of Science and Technology of China, Hefei, 230026, Anhui, China. chuanhai@ustc.edu.cn.ORCID 0000-0003-4354-3796
Yamei WangState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, 361102, Fujian, China. wangyamei@xmu.edu.cn.ORCID 0000-0003-3035-0178
Quan-Wen JinState Key Laboratory of Cellular Stress Biology, School of Life Sciences, Faculty of Medicine and Life Sciences, Xiamen University, Xiamen, 361102, Fujian, China. jinquanwen@xmu.edu.cn.ORCID 0000-0001-6146-6910
Xiamen University · CNUniversity of Science and Technology of China · CNUniversity of Massachusetts Chan Medical School · US

Funding

Regulation of Hippo pathway signaling by mechanical forcesR01GM058406 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MCCOLLUM, DANNEL · 1998 to 2023
$8.5M
NIGMS NIH HHS R01 GM058406
6 · The paper itself

Abstract

Microtubules play a crucial role during the establishment and maintenance of cell polarity. In fission yeast cells, the microtubule plus-end tracking proteins (+TIPs) (including the CLIP-170 homologue Tip1) regulate microtubule dynamics and also transport polarity factors to the cell cortex. Here, we show that the E3 ubiquitin ligase Dma1 plays an unexpected role in controlling polarized growth through ubiquitinating Tip1. Dma1 colocalizes with Tip1 to cortical sites at cell ends, and is required for ubiquitination of Tip1. Although the absence of dma1

Indexed as

SchizosaccharomycesSchizosaccharomyces pombe ProteinsCalcineurinCell Cycle ProteinsDNA ReplicationMicrotubule-Associated ProteinsMicrotubulesNeoplasm ProteinsUbiquitinationUbiquitin-Protein LigasesCalcineurinCell Cycle Proteinscytoplasmic linker protein 170Dma1 protein, S pombeMicrotubule-Associated ProteinsNeoplasm ProteinsSchizosaccharomyces pombe ProteinsUbiquitin-Protein Ligases

Identifiers

PMID36138017
PMCPMC9499959
OpenAlexW4296690062

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.