ArticleHeart (British Cardiac Society)2023
Temporal association between invasive procedures and infective endocarditis.
Article in Heart (British Cardiac Society), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Risk of Infective Endocarditis Following Invasive Dental Procedures: A Systematic Review and Meta-Analysis.Public health reviews · 2024Pooled it
- Prophylactic antibiotic use for infective endocarditis: a systematic review and meta-analysis.BMJ open · 2023Pooled it
- Infective Endocarditis on Aortic Valve: From Diagnosis to Cardiac Surgical Intervention-Narrative Review.Journal of clinical medicine · 2026Review
- Infective Endocarditis: A Contemporary Review of Epidemiology, Diagnosis, and Management.Antibiotics (Basel, Switzerland) · 2026Review
- The Biological Cost of Every Heartbeat: Imaging-Derived Cardiovascular Vulnerability in Infective Endocarditis.International journal of molecular sciences · 2026Article
- Oral health and infective endocarditis among high-risk individuals: a nationwide register-based study.Journal of oral microbiology · 2026Article
- 2023 European Society of Cardiology guidelines for the management of infective endocarditis : Statement of endorsement by the NVVC Full version.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2026Review
- Necessity of dental restoration before heart valve replacement: a cross-sectional study of a historical cohort.Clinical oral investigations · 2025Article
- Endocarditis: Rising Incidence in the Post-COVID-19 Pandemic Era: A Narrative Review.Journal of clinical medicine · 2025Review
- Trends in Epidemiology, Clinical Characteristics, and Outcomes of Infective Endocarditis: A 16-Year Nationwide Cohort Study in Korea.Journal of Korean medical science · 2025Article
- Antibiotics in Mucogingival Surgery for Recession Treatment: A Narrative Review.Antibiotics (Basel, Switzerland) · 2025Review
- Mapping Review of the Correlations Between Periodontitis, Dental Caries, and Endocarditis.Dentistry journal · 2025Review
- Accuracy of Large Language Models for Infective Endocarditis Prophylaxis in Dental Procedures.International dental journal · 2025Article
- Increase in Oral Streptococcal Endocarditis Among Moderate-Risk Patients: Impact of Guideline Changes on Endocarditis Prevention.JACC. Advances · 2024Article
- Clinical profile, microbiology and outcomes in infective endocarditis treated with aortic valve replacement: a multicenter case-control study.BMC infectious diseases · 2024Article
- New evidence calls into question NICE's endocarditis prevention guidance.British dental journal · 2024Article
- Endocarditis prevention: time for a review of NICE guidance.The Lancet regional health. Europe · 2024Review
- Healthcare exposures and associated risk of endocarditis after open-heart cardiac valve surgery.BMC medicine · 2024Article
- Review
- Exploring links between oral health and infective endocarditis.Frontiers in oral health · 2024Review
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
objectiveAntibiotic prophylaxis has been recommended for patients at increased risk of infective endocarditis (IE) undergoing specific invasive procedures (IPs) despite a lack of data supporting its use. Therefore, antibiotic prophylaxis recommendations ceased in the mid-2000s for all but those at high IE risk undergoing invasive dental procedures. We aimed to quantify any association between IPs and IE.
methodsAll 14 731 IE hospital admissions in England between April 2010 and March 2016 were identified from national admissions data, and medical records were searched for IP performed during the 15-month period before IE admission. We compared the incidence of IP during the 3 months immediately before IE admission (case period) with the incidence during the preceding 12 months (control period) to determine whether the odds of developing IE were increased in the 3 months after certain IP.
resultsThe odds of IE were increased following permanent pacemaker and defibrillator implantation (OR 1.54, 95% CI 1.27 to 1.85, p<0.001), extractions/surgical tooth removal (OR 2.14, 95% CI 1.22 to 3.76, p=0.047), upper (OR 1.58, 95% CI 1.34 to 1.85, p<0.001) and lower gastrointestinal endoscopy (OR 1.66, 95% CI 1.35 to 2.04, p<0.001) and bone marrow biopsy (OR 1.76, 95% CI 1.16 to 2.69, p=0.039). Using an alternative analysis, bronchoscopy (OR 1.33, 95% CI 1.06 to 1.68, p=0.049) and blood transfusions/red cell/plasma exchange (OR 1.2, 95% CI 1.07 to 1.35, p=0.012) were also associated with IE.
conclusionsThis study identifies a significant association between specific IPs (permanent pacemaker and defibrillator implantation, dental extraction, gastrointestinal endoscopy and bronchoscopy) and subsequent IE that warrants re-evaluation of current antibiotic prophylaxis recommendations to prevent IE in high IE risk individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.