Evidence map›Paper›PMID 36137649›Full record

ReviewJournal for immunotherapy of cancer2022

Imaging cellular immunotherapies and immune cell biomarkers: from preclinical studies to patients.

Alessia Volpe, Prasad S Adusumilli, Heiko Schöder, Vladimir Ponomarev

Open access · goldAbstract readReview
In one paragraph

Review in Journal for immunotherapy of cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.0field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Reengineered Anti-CD4 Cys-diabody Variants forMolecular imaging and biology · 2025
    Article
  8. Article
  9. Article
  10. Rapid fabrication and dissolution of pressedEJNMMI radiopharmacy and chemistry · 2025
    Article
  11. Specific imaging of CD8 + T-Cell dynamics with a nanobody radiotracer against human CD8β.European journal of nuclear medicine and molecular imaging · 2024
    Article
  12. Review
  13. Finding Your CAR: The Road Ahead for Engineered T Cells.The American journal of pathology · 2024
    Review
  14. Article
  15. Noninvasive longitudinal PET/CT imaging of CAR T cells using PSMA reporter gene.European journal of nuclear medicine and molecular imaging · 2024
    Article
  16. Insights into innate immune cell evasion byFrontiers in immunology · 2024
    Review
  17. Review
  18. Review
  19. Molecular imaging to support cancer immunotherapy.Journal for immunotherapy of cancer · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Alessia VolpeDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.ORCID 0000-0003-3087-9178
Prasad S AdusumilliThoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Heiko SchöderDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Vladimir PonomarevDepartment of Radiology, Memorial Sloan Kettering Cancer Center, New York, New York, USA ponomarv@mskcc.org.ORCID 0000-0002-9119-9128
Memorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
A phase I/II combination immunotherapy clinical trial: mesothelin-targeted chimeric antigen receptor T cells and checkpoint blockade agent in pleural mesotheliomaR01CA235667 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI ADUSUMILLI, PRASAD S. · 2019 to 2024
$3.6M
Imaging Immune Modulation in Chimeric Antigen Receptor (CAR) T Cell TherapyR01CA204924 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI PONOMAREV, VLADIMIR · 2016 to 2020
$3.5M
Image-guided TRAIL-enhanced CAR T-cell immunotherapyR01CA220524 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI PONOMAREV, VLADIMIR · 2018 to 2022
$2.9M
Image-guided irreversible electroporation directed CAR T-cell delivery to solid tumorsR01CA236615 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI ADUSUMILLI, PRASAD S., SOLOMON, STEPHEN BARNETT · 2018 to 2022
$2.0M
Secretable theranostic payloads to augment the efficacy of adoptive CAR-T cell therapiesR21CA250478 · NCI · SLOAN-KETTERING INST CAN RESEARCH · PI PONOMAREV, VLADIMIR · 2020 to 2020
$455k
NCI NIH HHS P30 CA008748NCI NIH HHS R01 CA204924NCI NIH HHS R01 CA220524NCI NIH HHS R01 CA235667NCI NIH HHS R01 CA236615NCI NIH HHS R21 CA250478
6 · The paper itself

Abstract

Cellular immunotherapies have emerged as a successful therapeutic approach to fight a wide range of human diseases, including cancer. However, responses are limited to few patients and tumor types. An in-depth understanding of the complexity and dynamics of cellular immunotherapeutics, including what is behind their success and failure in a patient, the role of other immune cell types and molecular biomarkers in determining a response, is now paramount. As the cellular immunotherapy arsenal expands, whole-body non-invasive molecular imaging can shed a light on their

Indexed as

ImmunotherapyNeoplasmsBiomarkers, TumorHumansTreatment OutcomeBiomarkers, TumorAdaptive ImmunityImmunotherapy, AdoptiveReceptors, Chimeric Antigen

Identifiers

PMID36137649
PMCPMC9511655
OpenAlexW4296687630

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.