Evidence map›Paper›PMID 36137629›Full record

ArticleBMJ open2022

Exercise-induced hypoalgesia after aerobic versus neck-specific exercise in people with acute/subacute whiplash-associated disorders: protocol for a randomised controlled trial.

Ernesto Anarte-Lazo, Carlos Bernal-Utrera, Mario Lopez-Amor, Eugenia Porras-Valencia, Francisco Javier Ruy-Diaz-Rojas, Deborah Falla, Cleofas Rodriguez-Blanco

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
In one paragraph

Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07546838 (Acute Effects of Aerobic Versus Combined Aerobic and Cervical-Upper Extremity Resistance Exercise on Pressure Pain Threshold, Pain Perception, and Fatigue in Workers Exposed to High Ergonomic Risk With Chronic Non-specific Neck Pain), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07546838 nacompletednot on this mapstarted 2025, after this paper: background citation

Acute Effects of Aerobic Versus Combined Aerobic and Cervical-Upper Extremity Resistance Exercise on Pressure Pain Threshold, Pain Perception, and Fatigue in Workers Exposed to High Ergonomic Risk With Chronic Non-specific Neck Pain: a Randomized Controlled Trial

TypeinterventionalSponsorHacettepe UniversityRan2025 to 2025Enrolled78ConditionsNeck Pain Musculoskeletal, Work Related Musculoskeletal DisordersArmsAerobic Exercise, Combined Exercise, Informed Control
3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 citations in OpenAlex.

  1. Trial
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Ernesto Anarte-LazoCentre of Precision Rehabilitation for Spinal Pain (CPR Spine), School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK.
Carlos Bernal-UtreraDepartment of Physiotherapy, University of Seville, Sevilla, Andalucía, Spain.
Mario Lopez-AmorDepartment of Physiotherapy, Clinica San Vicente, Madrid, Spain.
Eugenia Porras-ValenciaDepartment of Physiotherapy, Clinica San Vicente, Madrid, Spain.
Francisco Javier Ruy-Diaz-RojasDepartment of Physiotherapy, Clinica San Vicente, Madrid, Spain.
Deborah FallaCentre of Precision Rehabilitation for Spinal Pain (CPR Spine), School of Sport, Exercise and Rehabilitation Sciences, University of Birmingham, Birmingham, UK d.falla@bham.ac.uk.ORCID 0000-0003-1689-6190
Cleofas Rodriguez-BlancoDepartment of Physiotherapy, University of Seville, Sevilla, Andalucía, Spain.
Clínica Rementería · ESUniversity of Almería · ESUniversidad de Sevilla · ESUniversity of Birmingham · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionA disturbance in exercise-induced hypoalgesia (EIH) has been observed in patients with chronic whiplash-associated disorders (WAD). Yet, no studies have examined whether EIH occurs in people with acute/subacute WAD. This study will determine whether EIH occurs immediately after and 24 hours after aerobic exercise (AE) and neck-specific exercise (NSE) in people with acute/subacute WAD. METHODS AND ANALYSIS: A randomised controlled trial has been designed and is reported in line with the Standard Protocol Items: Recommendations for Interventional Trials. EIH will be assessed immediately after and 24 hours after AE, NSE and a control intervention (randomly allocated). As dependent variables of the study, we will measure pressure pain thresholds measured over the region of the spinous process of C2 and C5, the muscle belly of the tibialis anterior and over the three main peripheral nerve trunks, Neck Pain Intensity, Neck-Disability Index, Pain Catastrophizing Scale, Tampa Scale Kinesiophobia-11, self-reported Leeds Assessment of Neuropathic Symptoms and Signs Scale. ETHICS APPROVAL AND DISSEMINATION: Ethical approval has been granted by the Ethics Committee from University Rey Juan Carlos (Madrid, Spain; reference number 0707202116721). The results of this study will be disseminated through presentations at scientific conferences and publication in scientific journals. TRIAL REGISTRATION NUMBER: RBR-9tqr2jt, https://ensaiosclinicos.gov.br/observador/submissao/sumario/11551.

Indexed as

Whiplash InjuriesAcute DiseaseChronic DiseaseExerciseExercise TherapyHumansNeck PainPain ThresholdRandomized Controlled Trials as TopicMusculoskeletal disordersPAIN MANAGEMENTRehabilitation medicineSpine

Identifiers

PMID36137629
PMCPMC9511575
OpenAlexW4296663472

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.