Evidence map›Paper›PMID 36137547›Full record

ArticleCurrent biology : CB2022

ATM/ATR kinases link the synaptonemal complex and DNA double-strand break repair pathway choice.

Laura I Láscarez-Lagunas, Saravanapriah Nadarajan, Marina Martinez-Garcia, Julianna N Quinn, Elena Todisco, Tanuj Thakkar, Elizaveta Berson, Don Eaford, Oliver Crawley, Alex Montoya and 9 more

Open access · greenAbstract read
In one paragraph

Article in Current biology : CB, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

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  6. Improved synapsis dynamics accompany meiotic stability inProceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 6 institutions in 3 countries.

Laura I Láscarez-LagunasDepartment of Genetics, Blavatnik Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Room 334, Boston, MA 02115, USA.
Saravanapriah NadarajanDepartment of Genetics, Blavatnik Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Room 334, Boston, MA 02115, USA.
Marina Martinez-GarciaDepartment of Genetics, Blavatnik Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Room 334, Boston, MA 02115, USA.
Julianna N QuinnDepartment of Genetics, Blavatnik Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Room 334, Boston, MA 02115, USA.
Elena TodiscoDepartment of Genetics, Blavatnik Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Room 334, Boston, MA 02115, USA.
Tanuj ThakkarDepartment of Genetics, Blavatnik Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Room 334, Boston, MA 02115, USA.
Elizaveta BersonDepartment of Genetics, Blavatnik Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Room 334, Boston, MA 02115, USA.
Don EafordDepartment of Genetics, Blavatnik Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Room 334, Boston, MA 02115, USA.
Oliver CrawleyMRC London Institute of Medical Sciences (LMS), Faculty of Medicine, Imperial College London, Du Cane Road, London W12 0NN, UK.
Alex MontoyaMRC London Institute of Medical Sciences (LMS), Faculty of Medicine, Imperial College London, Du Cane Road, London W12 0NN, UK.
Peter FaullMRC London Institute of Medical Sciences (LMS), Faculty of Medicine, Imperial College London, Du Cane Road, London W12 0NN, UK.
Nuria FerrandizMRC London Institute of Medical Sciences (LMS), Faculty of Medicine, Imperial College London, Du Cane Road, London W12 0NN, UK.
Consuelo BarrosoMRC London Institute of Medical Sciences (LMS), Faculty of Medicine, Imperial College London, Du Cane Road, London W12 0NN, UK.
Sara LabellaMcGill University, Biology Department, Stewart Biology Building, Room W5/24 1205 Dr. Penfield Avenue, Montreal, QC H3A1B1, Canada.
Emily KouryDepartment of Biology, The University of Iowa, Biology Building, Room 308, 129 E. Jefferson, Iowa City, IA 52242-1324, USA.
Sarit SmolikoveDepartment of Biology, The University of Iowa, Biology Building, Room 308, 129 E. Jefferson, Iowa City, IA 52242-1324, USA.
Monique ZetkaMcGill University, Biology Department, Stewart Biology Building, Room W5/24 1205 Dr. Penfield Avenue, Montreal, QC H3A1B1, Canada.
Enrique Martinez-PerezMRC London Institute of Medical Sciences (LMS), Faculty of Medicine, Imperial College London, Du Cane Road, London W12 0NN, UK.
Monica P ColaiácovoDepartment of Genetics, Blavatnik Institute, Harvard Medical School, 77 Avenue Louis Pasteur, Room 334, Boston, MA 02115, USA. Electronic address: mcolaiacovo@genetics.med.harvard.edu.
Boston VA Research Institute · USMRC London Institute of Medical Sciences · GBHarvard University · USMcGill University · CAUniversity of Iowa · USImperial College London · GB

Funding

Synaptonemal Complex Assembly and Function in MeiosisR01GM072551 · NIGMS · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI Monica P Colaiacovo · 2005 to 2026
$7.5M
Diversity in Biomedical Sciences Via Personalized Research and Education Programs for Post-BaccalaureatesR25GM109436 · NIGMS · HARVARD UNIVERSITY · PI D'SOUZA, VICTORIA MANUEL, VELEZ-RUIZ, GISSELLE A · 2016 to 2024
$2.5M
Medical Research Council MC_U120097113NIGMS NIH HHS R01 GM072551NIGMS NIH HHS R25 GM109436
6 · The paper itself

Abstract

DNA double-strand breaks (DSBs) are deleterious lesions, which must be repaired precisely to maintain genomic stability. During meiosis, programmed DSBs are repaired via homologous recombination (HR) while repair using the nonhomologous end joining (NHEJ) pathway is inhibited, thereby ensuring crossover formation and accurate chromosome segregation.

Indexed as

Caenorhabditis elegans ProteinsDNA Breaks, Double-StrandedAnimalsCaenorhabditis elegansDNADNA RepairMeiosisNuclear ProteinsSynaptonemal ComplexCaenorhabditis elegans ProteinsDNANuclear ProteinsSYP-4 protein, C elegansATM/ATRC. elegansCO patterningDSBmeiosisNHEJsynaptonemal complexSYP-4

Identifiers

PMID36137547
PMCPMC9643613
OpenAlexW4296801532

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.