Evidence map›Paper›PMID 36137524›Full record

GuidelineDermatology (Basel, Switzerland)2023

Swiss Recommendations for Cutaneous Basal Cell Carcinoma.

Egle Ramelyte, Mirjam C Nägeli, Robert Hunger, Rastine Merat, Olivier Gaide, Alexander A Navarini, Antonio Cozzio, Nikolaus B Wagner, Lara Valeska Maul, Reinhard Dummer

Open access · hybridAbstract readPractice GuidelineReview
In one paragraph

Guideline in Dermatology (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Plasmonic nanophotothermal therapy: Destruction of 500 mmSkin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2024
    Article
  6. Review
  7. Review
  8. Non-Surgical Therapeutic Strategies for Non-Melanoma Skin Cancers.Current treatment options in oncology · 2023
    Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Egle RamelyteDepartment of Dermatology, University Hospital Zurich, Zurich, Switzerland.
Mirjam C NägeliDepartment of Dermatology, University Hospital Zurich, Zurich, Switzerland.
Robert HungerDepartment of Dermatology, Inselspital, Bern University Hospital, Bern, Switzerland.
Rastine MeratDivision of Dermatology and Venereology, Geneva University Hospital, Geneva, Switzerland.
Olivier GaideDepartment of Radiation Oncology, Lausanne University Hospital, Lausanne, Switzerland.
Alexander A NavariniDepartment of Dermatology, University Hospital Basel, Basel, Switzerland.
Antonio CozzioClinic of Dermatology, Venereology and Allergology, St. Gallen Hospital, St. Gallen, Switzerland.
Nikolaus B WagnerClinic of Dermatology, Venereology and Allergology, St. Gallen Hospital, St. Gallen, Switzerland.
Lara Valeska MaulDepartment of Dermatology, University Hospital Basel, Basel, Switzerland.
Reinhard DummerDepartment of Dermatology, University Hospital Zurich, Zurich, Switzerland.
University Hospital of Zurich · CHUniversity Hospital of Basel · CHUniversity of St.Gallen · CHUniversity Hospital of Bern · CHUniversity Hospital of Geneva · CHUniversity of Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Basal cell carcinoma (BCC) is the most common nonmelanoma skin cancer in Switzerland and worldwide. Most BCCs can be treated in a curative setting. However, patients can develop locally destructive and, rarely, metastatic tumors that require a different treatment approach. The clinical subtype of individual lesions provides prognostic information and influences management decisions. Surgical excision, topical therapies, and radiotherapy are highly effective in the majority of subtypes as well as in low- and high-risk diseases. For patients with low-risk diseases and superficial tumors not amenable to surgery, several nonsurgical alternatives are available. Systemic therapy is indicated for high-risk BCCs, which are not amenable to either surgery or radiotherapy. Hedgehog pathway inhibitors (HHI) are currently approved. Other therapeutic options such as immune checkpoint inhibitors show promising results in clinical trials. This first version of Swiss recommendations for diagnosis and management of BCC was prepared through extensive literature review and an advisory board consensus of expert dermatologists and oncologists in Switzerland. The present guidelines recommend therapies based on a multidisciplinary team approach and rate of recurrence for individual lesions. Based on the risk of recurrence, two distinct groups have been identified: low-risk (easy-to-treat) and high-risk (difficult-to-treat) tumors. Based on these classifications, evidence-based recommendations of available therapies are presented herein.

Indexed as

Antineoplastic AgentsBasal Cell CarcinomaSkin NeoplasmsHedgehog ProteinsHumansSwitzerlandAntineoplastic AgentsHedgehog ProteinsBasal cell carcinomaHedgehog pathway inhibitorsLocally advanced tumorMetastatic tumorPD-1 inhibitors

Identifiers

PMID36137524
PMCPMC9808659
OpenAlexW4296802554

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.