Evidence map›Paper›PMID 36137028›Full record

ArticleScience (New York, N.Y.)2022

A coagulation factor moonlights in the heart.

Dan Tong, Joseph A Hill

Abstract readComment
PubMed Publisher
In one paragraph

Article in Science (New York, N.Y.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Dan TongDepartment of Internal Medicine (Cardiology), University of Texas Southwestern Medical Center, Dallas, TX, USA.
Joseph A HillDepartment of Internal Medicine (Cardiology), University of Texas Southwestern Medical Center, Dallas, TX, USA.
The University of Texas Southwestern Medical Center · US

Funding

Cardiomyocyte bromodomain protein 4 (BRD4) in physiology and diseaseR01HL147933 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI HILL, JOSEPH A · 2020 to 2023
$2.5M
ETS2-dependent control in cardiomyocyte ischemia/reperfusion injuryR01HL164586 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI GILLETTE, THOMAS G, HILL, JOSEPH A · 2022 to 2025
$2.5M
Molecular Mechanisms of HFpEF-associated Atrial FibrillationR01HL155765 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI GILLETTE, THOMAS G, HILL, JOSEPH A · 2021 to 2024
$1.6M
Mechanisms of obesity-dependent alterations in cardiomyocyte metabolismR01HL128215 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI HILL, JOSEPH A · 2017 to 2020
$1.6M
Protein acetylation-dependent fatty acid metabolic dysfunction in HFpEFK08HL157697 · NHLBI · UT SOUTHWESTERN MEDICAL CENTER · PI Dan Tong · 2022 to 2026
$738k
NHLBI NIH HHS K08 HL157697NHLBI NIH HHS R01 HL128215NHLBI NIH HHS R01 HL147933NHLBI NIH HHS R01 HL155765NHLBI NIH HHS R01 HL164586
6 · The paper itself

Abstract

Liver-derived coagulation factor XI protects the heart from failure.

Indexed as

Bone Morphogenetic Protein 7Factor XIHeart FailureLiverLiver DiseasesMyocardiumAnimalsHumansMiceBone Morphogenetic Protein 7Factor XI

Identifiers

PMID36137028
OpenAlexW4296800144

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.