Evidence map›Paper›PMID 36136883›Full record

ArticleTomography (Ann Arbor, Mich.)2022

Cytoreductive Surgical Treatment of Pleural Mesothelioma in a Porcine Model Using Magnetic-Resonance-Guided Focused Ultrasound Surgery (MRgFUS) and Radiofrequency Ablation (RFA).

Marcia Costa, Carolina Fernandes, Matt Eames, Arik Hananel, John P Mugler, Jhosep Huaromo, Jack B Yang, Jaime Mata

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tomography (Ann Arbor, Mich.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Marcia CostaFaculdade de Ciencias, Universidade de Lisboa, 1749-016 Lisboa, Portugal.
Carolina FernandesFaculdade de Ciencias, Universidade de Lisboa, 1749-016 Lisboa, Portugal.
Matt EamesFocused Ultrasound Foundation, Charlottesville, VA 22903, USA.
Arik HananelFocused Ultrasound Foundation, Charlottesville, VA 22903, USA.
John P MuglerDepartment of Radiology & Medical Imaging, University of Virginia, Charlottesville, VA 22903, USA.
Jhosep HuaromoDepartment of Radiology & Medical Imaging, University of Virginia, Charlottesville, VA 22903, USA.
Jack B YangDepartment of Radiology & Medical Imaging, University of Virginia, Charlottesville, VA 22903, USA.ORCID 0000-0002-3613-9448
Jaime MataDepartment of Radiology & Medical Imaging, University of Virginia, Charlottesville, VA 22903, USA.
University of Virginia · USFocused Ultrasound Foundation · USUniversity of Lisbon · PT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A combination of surgery and chemotherapy is the most effective treatment available for Malignant Pleural Mesothelioma (MPM). However, both cause significant collateral damage and cannot eliminate residual microscopic disease. This investigation aimed to compare and determine the feasibility of utilizing Radiofrequency Ablation (RFA) and Magnetic-Resonance-guided Focused Ultrasound Surgery (MRgFUS) as alternative treatments for MPM. A large animal tumor model was developed in 13 Yorkshire female pigs using the MSTO211H cell line. Two pigs were initially used to determine the cyclosporine dose required for immunosuppression and tumor development. Subsequently, 11 other pigs underwent tumor development. Of these 11, 2 died during cell inoculation. Small tumor masses and adhesions were present in the other 9, indicating mesothelioma development. Five pigs then received RFA treatment, and 4 pigs received MRgFUS treatment. Tumor model development and effect of the two treatments were examined using MRI and by necropsy. RFA and MRgFUS both successfully ablated approximately the same sized area in the same treatment time. This study demonstrates that RFA and MRgFUS are feasible for tumor debulking, and while MRgFUS requires more pretreatment planning compared to RFA, MRgFUS is a completely noninvasive procedure.

Indexed as

Catheter AblationCyclosporinsMagnetic Resonance Imaging, InterventionalMesothelioma, MalignantAnimalsCytoreduction Surgical ProceduresFemaleMagnetic Resonance ImagingSwineCyclosporinshigh-intensity focused ultrasoundmagnetic resonance imagingmesotheliomaradiofrequency ablation

Identifiers

PMID36136883
PMCPMC9498358
OpenAlexW4294957978

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.