Evidence map›Paper›PMID 36136717›Full record

ArticleVeterinary sciences2022

Distribution of Coronavirus Receptors in the Swine Respiratory and Intestinal Tract.

Rahul Kumar Nelli, James Allen Roth, Luis Gabriel Gimenez-Lirola

Open access · goldAbstract read
In one paragraph

Article in Veterinary sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Rahul Kumar NelliCollege of Veterinary Medicine, Iowa State University, Ames, IA 50010, USA.ORCID 0000-0001-8765-0943
James Allen RothCollege of Veterinary Medicine, Iowa State University, Ames, IA 50010, USA.
Luis Gabriel Gimenez-LirolaCollege of Veterinary Medicine, Iowa State University, Ames, IA 50010, USA.ORCID 0000-0002-4407-7996
Iowa State University · US

Funding

Iowa Livestock Health Advisory Council ILHAC, Award FY20
6 · The paper itself

Abstract

Coronaviruses use a broad range of host receptors for binding and cell entry, essential steps in establishing viral infections. This pilot study evaluated the overall distribution of angiotensin-converting enzyme 2 (ACE2), aminopeptidase N (APN), carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1), and dipeptidyl peptidase 4 (DPP4) receptors in the pig respiratory and intestinal tract. All the receptors evaluated in this study were expressed and differentially distributed through the respiratory and intestinal tract. The presence and expression levels of these receptors could determine susceptibility to coronavirus infections. This study may have important implications for the development of research models and the assessment of the potential risk and introduction of novel coronaviruses into the swine population.

Indexed as

ACE2APNCEACAM1coronavirus receptorsDPP4intestineslungswinetrachea

Identifiers

PMID36136717
PMCPMC9504008
OpenAlexW4296764896

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.