Evidence map›Paper›PMID 36136712›Full record

ArticleVeterinary sciences2022

Angiotensin II Blood Serum Levels in Piglets, after Intra-Dermal or Intra-Muscular Vaccination against PRRSV.

Georgios Maragkakis, Labrini V Athanasiou, Laskarina-Maria Korou, Serafeim C Chaintoutis, Chrysostomos Dovas, Despina N Perrea, Georgios Papakonstantinou, Georgios Christodoulopoulos, Dominiek Maes, Vasileios G Papatsiros

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary sciences, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 48% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Georgios MaragkakisClinic of Medicine, Faculty of Veterinary Medicine, University of Thessaly, 43100 Karditsa, Greece.
Labrini V AthanasiouClinic of Medicine, Faculty of Veterinary Medicine, University of Thessaly, 43100 Karditsa, Greece.ORCID 0000-0001-8723-2629
Laskarina-Maria KorouLaboratory for Experimental Surgery and Surgical Research, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Serafeim C ChaintoutisDiagnostic Laboratory, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54627 Thessaloniki, Greece.ORCID 0000-0003-1539-8237
Chrysostomos DovasDiagnostic Laboratory, School of Veterinary Medicine, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54627 Thessaloniki, Greece.ORCID 0000-0003-2947-1765
Despina N PerreaLaboratory for Experimental Surgery and Surgical Research, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Georgios PapakonstantinouClinic of Medicine, Faculty of Veterinary Medicine, University of Thessaly, 43100 Karditsa, Greece.
Georgios ChristodoulopoulosClinic of Medicine, Faculty of Veterinary Medicine, University of Thessaly, 43100 Karditsa, Greece.
Dominiek MaesDepartment of Internal Medicine, Reproduction and Population Medicine, Faculty of Veterinary Medicine, Ghent University, 9820 Merelbeke, Belgium.
Vasileios G PapatsirosClinic of Medicine, Faculty of Veterinary Medicine, University of Thessaly, 43100 Karditsa, Greece.ORCID 0000-0003-4955-0460
University of Thessaly · GRAristotle University of Thessaloniki · GRNational and Kapodistrian University of Athens · GRGhent University · BE

Funding

Intervet Hellas-MSD 5168
6 · The paper itself

Abstract

The Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) induces apoptosis in different organs. Angiotensin II (Ang II) is the main effector of the renin-angiotensin system and participates in apoptosis. Thus, this study aimed to investigate changes in piglet serum Ang II levels following intradermal (ID) and intramuscular (IM) vaccination with a commercial PRRS modified live virus (MLV) vaccine. The trial was conducted in a commercial pig farm, including 104 piglets which were randomly allocated to four groups: Group A-Porcilis PRRS ID, Group B-Porcilis PRRS IM, Group C-Diluvac ID and Group D-Diluvac IM. The study piglets were either vaccinated or injected at 2 weeks of age and they were tested by qRT-PCR for PRRSV and by ELISA for Ang II. The results indicated differences in viremia of tested piglets at 7 weeks of age, while piglets at 10 weeks of age were all found qRT-PCR positive for PRRSV. In addition, significant differences were noticed in Ang II in 7-week-old piglets. In conclusion, the present study provides evidence that ID vaccination induces less tissue damage, based on the lower measurements of Ang II in the serum of ID vaccinated piglets.

Indexed as

Ang IIintradermalpigporcine reproductive and respiratory syndromevaccine

Identifiers

PMID36136712
PMCPMC9503611
OpenAlexW4296764887

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.