Evidence map›Paper›PMID 36136618›Full record

ArticleTropical medicine and infectious disease2022

Can Biomarkers of Oxidative Stress in Serum Predict Disease Severity in West Nile Virus Infection? A Pilot Study.

Maxim Van Herreweghe, Annelies Breynaert, Tess De Bruyne, Corneliu Petru Popescu, Simin-Aysel Florescu, Yaniv Lustig, Eli Schwartz, Federico Giovanni Gobbi, Nina Hermans, Ralph Huits

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tropical medicine and infectious disease, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 4 countries.

Maxim Van HerrewegheNatuRA Research Group, Department of Pharmaceutical Sciences, University of Antwerp, 2610 Wilrijk, Belgium.ORCID 0000-0001-5490-0731
Annelies BreynaertNatuRA Research Group, Department of Pharmaceutical Sciences, University of Antwerp, 2610 Wilrijk, Belgium.ORCID 0000-0003-0831-615X
Tess De BruyneNatuRA Research Group, Department of Pharmaceutical Sciences, University of Antwerp, 2610 Wilrijk, Belgium.ORCID 0000-0001-8597-2084
Corneliu Petru PopescuDepartment of Adult Infectious and Tropical Diseases, Carola Davila University of Medicine and Pharmacy and Dr Victor Babeș Clinical Hospital of Infectious and Tropical Diseases, 030303 Bucharest, Romania.
Simin-Aysel FlorescuDepartment of Adult Infectious and Tropical Diseases, Carola Davila University of Medicine and Pharmacy and Dr Victor Babeș Clinical Hospital of Infectious and Tropical Diseases, 030303 Bucharest, Romania.ORCID 0000-0002-6482-3386
Yaniv LustigThe Central Virology Laboratory, Public Health Services, Ministry of Health, Sheba Medical Center, Tel Hashomer, Israel & Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 52621, Israel.
Eli SchwartzCenter for Geographic Medicine and Tropical Diseases, Sheba Medical Center, Tel Hashomer & Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv 52621, Israel.
Federico Giovanni GobbiIRCCS Ospedale Sacro Cuore Don Calabria, Department of Infectious Tropical Diseases and Microbiology, 37024 Verona, Italy.
Nina HermansNatuRA Research Group, Department of Pharmaceutical Sciences, University of Antwerp, 2610 Wilrijk, Belgium.ORCID 0000-0003-3946-7313
Ralph HuitsNatuRA Research Group, Department of Pharmaceutical Sciences, University of Antwerp, 2610 Wilrijk, Belgium.ORCID 0000-0001-8803-9468
University of Antwerp · BECarol Davila University of Medicine and Pharmacy · ROTel Aviv University · ILOspedale Sacro Cuore Don Calabria · IT

Funding

Flemish Government Antigoon ID 43642
6 · The paper itself

Abstract

West Nile virus (WNV) can cause asymptomatic infection in humans, result in self-limiting febrile illness, or lead to severe West Nile Neuroinvasive disease (WNND). We conducted a pilot study to compare selected biomarkers of oxidative stress in sera of viremic West Nile virus patients and asymptomatic infected blood donors to investigate their potential as predictors of disease severity. We found that total oxidant status was elevated in WNND and in uncomplicated WNV infections (median 9.05 (IQR 8.37 to 9.74) and 7.14 (7.03 to 7.25) µmol H

Indexed as

biomarkersFlaviviridaeoxidative stressWest Nile FeverWest Nile Neuroinvasive diseaseWest Nile virus

Identifiers

PMID36136618
PMCPMC9505794
OpenAlexW4293224470

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.