Evidence map›Paper›PMID 36136540›Full record

ArticleToxins2022

Purification and Mechanism of Microcystinase MlrC for Catalyzing Linearized Cyanobacterial Hepatotoxins Using

Qianwen Zou, Junhui Teng, Kunyan Wang, Yiming Huang, Qingbei Hu, Sisi Chen, Qianqian Xu, Haiyang Zhang, Duyuan Fang, Hai Yan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxins, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Qianwen ZouSchool of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, China.
Junhui TengSchool of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, China.
Kunyan WangSchool of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, China.
Yiming HuangSchool of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, China.
Qingbei HuSchool of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, China.
Sisi ChenSchool of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, China.
Qianqian XuSchool of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, China.
Haiyang ZhangSchool of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, China.ORCID 0000-0002-2410-7078
Duyuan FangBeijing Royal School, Beijing 102209, China.
Hai YanSchool of Chemistry and Biological Engineering, University of Science and Technology Beijing, Beijing 100083, China.
University of Science and Technology Beijing · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cyanobacterial hepatotoxins, including microcystins (MCs) and nodularins (NODs), are widely produced, distributed and extremely hazardous to human beings and the environment. However, the catalytic mechanism of microcystinase for biodegrading cyanobacterial hepatotoxins is not completely understood yet. The first microcystinase (MlrA) catalyzes the ring opening of cyclic hepatotoxins, while being further hydrolyzed by the third microcystinase (MlrC). Based on the homology modeling, we postulated that MlrC of

Indexed as

CyanobacteriaSphingomonadaceaeBiodegradation, EnvironmentalHumansMicrocystinsPeptides, CyclicMicrocystinsPeptides, Cyclicactive sitecyanobacterial hepatotoxinsmechanismmicrocystinase (MlrC)

Identifiers

PMID36136540
PMCPMC9506587
OpenAlexW4294233583

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.