Evidence map›Paper›PMID 36136538›Full record

ArticleToxins2022

µ-Conotoxins Targeting the Human Voltage-Gated Sodium Channel Subtype Na

Kirsten L McMahon, Hue N T Tran, Jennifer R Deuis, David J Craik, Irina Vetter, Christina I Schroeder

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxins, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Kirsten L McMahonInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
Hue N T TranInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0001-5181-1899
Jennifer R DeuisInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.
David J CraikInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0003-0007-6796
Irina VetterInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0002-3594-9588
Christina I SchroederInstitute for Molecular Bioscience, The University of Queensland, Brisbane, QLD 4072, Australia.ORCID 0000-0002-6737-6374
The University of Queensland · AUNational Institutes of Health · US

Funding

Discovery and development of voltage-gated sodium channel inhibitorsZIABC012003 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI SCHROEDER, INGRID · 2020 to 2022
$291k
Intramural NIH HHS ZIA BC012003NIH HHS ZIABS012003
6 · The paper itself

Abstract

µ-Conotoxins are small, potent, peptide voltage-gated sodium (Na

Indexed as

ConotoxinsVoltage-Gated Sodium Channel BlockersAnalgesicsAnimalsCysteineHumansNAV1.4 Voltage-Gated Sodium ChannelNAV1.7 Voltage-Gated Sodium ChannelPeptidesAnalgesicsConotoxinsCysteineNAV1.4 Voltage-Gated Sodium ChannelNAV1.7 Voltage-Gated Sodium ChannelPeptidesVoltage-Gated Sodium Channel BlockersCys frameworksdisulfide-rich peptidesstructure-activity relationshipsvoltage-gated sodium channelsµ-conotoxins

Identifiers

PMID36136538
PMCPMC9506549
OpenAlexW4293770711

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.