Evidence map›Paper›PMID 36136464›Full record

ReviewToxics2022

Medicinal Plant Growth in Heavy Metals Contaminated Soils: Responses to Metal Stress and Induced Risks to Human Health.

Raluca Maria Hlihor, Mihaela Roșca, Laura Hagiu-Zaleschi, Isabela Maria Simion, Gabriel Mihăiță Daraban, Vasile Stoleru

Open access · goldAbstract readReview
In one paragraph

Review in Toxics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
8.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 88 citations in OpenAlex.

  1. Heavy metals and pesticides in medicinal plants: environmental sources, plant responses, and human health risk assessment.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Synergistic Effects ofPlants (Basel, Switzerland) · 2025
    Article
  8. Article
  9. Article
  10. Heavy Metals Alter the Anti-cancer Potency of Medicinal Plants.Anti-cancer agents in medicinal chemistry · 2025
    Review
  11. Review
  12. Article
  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Current Trends for Lavender (Plants (Basel, Switzerland) · 2023
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Raluca Maria HlihorDepartment of Horticultural Technologies, Faculty of Horticulture, "Ion Ionescu de la Brad" Iasi University of Life Sciences, 3 Mihail Sadoveanu Alley, 700490 Iasi, Romania.ORCID 0000-0003-2428-3669
Mihaela RoșcaDepartment of Horticultural Technologies, Faculty of Horticulture, "Ion Ionescu de la Brad" Iasi University of Life Sciences, 3 Mihail Sadoveanu Alley, 700490 Iasi, Romania.ORCID 0000-0002-1405-0848
Laura Hagiu-ZaleschiDepartment of Horticultural Technologies, Faculty of Horticulture, "Ion Ionescu de la Brad" Iasi University of Life Sciences, 3 Mihail Sadoveanu Alley, 700490 Iasi, Romania.
Isabela Maria SimionDepartment of Horticultural Technologies, Faculty of Horticulture, "Ion Ionescu de la Brad" Iasi University of Life Sciences, 3 Mihail Sadoveanu Alley, 700490 Iasi, Romania.ORCID 0000-0001-9086-6198
Gabriel Mihăiță DarabanDepartment of Organic, Biochemical and Food Engineering, "Cristofor Simionescu" Faculty of Chemical Engineering and Environmental Protection, "Gheorghe Asachi" Technical University of Iasi, 73 Prof. D. Mangeron Blvd., 700050 Iasi, Romania.
Vasile StoleruDepartment of Horticultural Technologies, Faculty of Horticulture, "Ion Ionescu de la Brad" Iasi University of Life Sciences, 3 Mihail Sadoveanu Alley, 700490 Iasi, Romania.ORCID 0000-0003-0485-0312
"Ion Ionescu de la Brad" Iasi University of Life Sciences · ROGheorghe Asachi Technical University of Iași · RO

Funding

Unitatea Executiva Pentru Finantarea Invatamantului Superior a Cercetarii Dezvoltarii si Inovarii PN-III-P1-1.1-TE-2019-1200, contract no. 120/2020
6 · The paper itself

Abstract

Accelerating heavy metal pollution is a hot issue due to a continuous growth in consumerism and increased activities in various global industries. Soil contamination with heavy metals has resulted in their incorporation into the human food web via plant components. Accumulation and amplification of heavy metals in human tissues through the consumption of medicinal plants can have hazardous health outcomes. Therefore, in this critical review we aim to bring together published information on this subject, with a special highlight on the knowledge gaps related to heavy metal stress in medicinal plants, their responses, and human health related risks. In this respect, this review outlines the key contamination sources of heavy metals in plants, as well as the absorption, mobilization and translocation of metal ions in plant compartments, while considering their respective mechanisms of detoxification. In addition, this literature review attempts to highlight how stress and defensive strategies operate in plants, pointing out the main stressors, either biotic or abiotic (e.g., heavy metals), and the role of reactive oxygen species (ROS) in stress answers. Finally, in our research, we further aim to capture the risks caused by heavy metals in medicinal plants to human health through the assessment of both a hazard quotient (HQ) and hazard index (HI).

Indexed as

detoxification mechanismsmedicinal plantsplant responses to abiotic stressreactive oxygen speciestoxic metals

Identifiers

PMID36136464
PMCPMC9504071
OpenAlexW4293770748

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.