Evidence map›Paper›PMID 36136285›Full record

ArticleMolecular and cellular biochemistry2023

Twist alters the breast tumor microenvironment via choline kinase to facilitate an aggressive phenotype.

Farhad Vesuna, Marie-France Penet, Noriko Mori, Zaver M Bhujwalla, Venu Raman

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular and cellular biochemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 60% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. The Role of the Fox Gene in Breast Cancer Progression.International journal of molecular sciences · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 2 countries.

Farhad VesunaDivision of Cancer Imaging Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Marie-France PenetDivision of Cancer Imaging Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Noriko MoriDivision of Cancer Imaging Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Zaver M BhujwallaDivision of Cancer Imaging Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Venu RamanDivision of Cancer Imaging Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. vraman2@jhmi.edu.ORCID http://orcid.org/0000-0003-2322-1423
Johns Hopkins University · US

Funding

HOSTILE ENVIRONMENTS PROMOTE INVASION AND METATASISR01CA082337 · NCI · JOHNS HOPKINS UNIVERSITY · PI BHUJWALLA, ZAVER M. · 1999 to 2024
$5.1M
Functional Imaging of Twist induced breast cancerR01CA140226 · NCI · JOHNS HOPKINS UNIVERSITY · PI RAMAN, VENU · 2010 to 2014
$1.6M
The Role of HOXA5 in Breast CancerR01CA097226 · NCI · JOHNS HOPKINS UNIVERSITY · PI RAMAN, VENU · 2004 to 2008
$1.5M
NCI NIH HHS R01 CA082337NCI NIH HHS R01 CA097226NCI NIH HHS R01 CA140226NIH HHS R01CA082337NIH HHS R01CA097226
6 · The paper itself

Abstract

Twist (TWIST1) is a gene required for cell fate specification in embryos and its expression in mammary epithelium can initiate tumorigenesis through the epithelial-mesenchymal transition. To identify downstream target genes of Twist in breast cancer, we performed microarray analysis on the transgenic breast cancer cell line, MCF-7/Twist. One of the targets identified was choline kinase whose upregulation resulted in increased cellular phosphocholine and total choline containing compounds-a characteristic observed in highly aggressive metastatic cancers. To study the interactions between Twist, choline kinase, and their effect on the microenvironment, we used

Indexed as

Choline KinasePhosphorylcholineCell Line, TumorCholineNuclear ProteinsPhenotypeTumor MicroenvironmentTwist-Related Protein 1CholineCholine KinaseNuclear ProteinsPhosphorylcholineTWIST1 protein, humanTwist-Related Protein 1Breast cancerCellular signalingMagnetic resonance spectroscopyMetastasisVascular permeabilityVascular volume

Identifiers

PMID36136285
PMCPMC11299248
OpenAlexW4296633047

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.