Evidence map›Paper›PMID 36136124›Full record

ArticleJournal of pediatric gastroenterology and nutrition2022

Safety of Thioguanine in Pediatric Inflammatory Bowel Disease: A Multi-Center Case Series.

Ahmed B Bayoumy, Jasmijn Z Jagt, Herbert M van Wering, Lissy de Ridder, Thalia Hummel, Victorien M Wolters, Janneke Stapelbroek, Marc A Benninga, Chris J J Mulder, Nanne K H de Boer and 2 more

Open access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of pediatric gastroenterology and nutrition, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Guideline
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 9 institutions in 1 country.

Ahmed B BayoumyFrom the Faculty of Medicine, Amsterdam UMC, University of Amsterdam, Amsterdam, the Netherlands.
Jasmijn Z Jagtthe Department of Pediatric Gastroenterology, Emma Children's Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Herbert M van Weringthe Department of Pediatric Gastroenterology, Amphia Hospital, Breda, the Netherlands.
Lissy de Ridderthe Department of Pediatric Gastroenterology, Erasmus MC Sophia Children's Hospital, Rotterdam, the Netherlands.
Thalia Hummelthe Department of Pediatric Gastroenterology, Medisch Spectrum Twente, Enschede, the Netherlands.
Victorien M Woltersthe Department of Pediatric Gastroenterology, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, the Netherlands.
Janneke Stapelbroekthe Department of Pediatric Gastroenterology, Catharina Hospital, Eindhoven, the Netherlands.
Marc A Benningathe Department of Pediatric Gastroenterology and Nutrition, Emma Children's Hospital, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, the Netherlands.
Chris J J Mulderthe Department of Gastroenterology and Hepatology, Amsterdam Gastroenterology and Metabolism Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Nanne K H de Boerthe Department of Gastroenterology and Hepatology, Amsterdam Gastroenterology and Metabolism Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Tim G J de Meijthe Department of Pediatric Gastroenterology, Emma Children's Hospital, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
Kids with Crohn’s, Colitis (KiCC) Working Group for Collaborative Paediatric IBD Research in the Netherlands
University of Amsterdam · NLVrije Universiteit Amsterdam · NLAmphia Ziekenhuis · NLAmsterdam University Medical Centers · NLEmma Kinderziekenhuis · NLErasmus MC - Sophia Children’s Hospital · NLMedisch Spectrum Twente · NLRadboud University Nijmegen · NLWilhelmina Children's Hospital · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThioguanine (TG) has been shown as a safe alternative in adults with inflammatory bowel disease (IBD) who did not tolerate conventional thiopurines [azathioprine (AZA)/mercaptopurine]. However, data in pediatric IBD are scarce. Therefore, we aimed to assess the safety of TG as maintenance therapy.

methodsA retrospective, multicenter cohort study of children with IBD on TG was performed in the Netherlands. TG-related adverse events (AE) were assessed and listed according to the common terminology criteria for AE.

resultsThirty-six children with IBD (median age 14.5 years) on TG (median dose 15 mg/day) were included in 6 centers. Five AE occurred during follow-up [pancreatitis (grade 3), hepatotoxicity (grade 3) (n = 2), Clostridium difficile infection (grade 2), and abdominal pain (grade 2)]. All patients (n = 8) with a previously AZA-induced pancreatitis did not redevelop pancreatitis on TG.

conclusionsIn pediatric IBD, TG seems a safe alternative in case of AZA-induced pancreatitis. Further research assessing long-term TG-related safety and efficacy is needed.

Indexed as

Inflammatory Bowel DiseasesPancreatitisAdolescentAdultAzathioprineChildChronic DiseaseCohort StudiesHumansImmunosuppressive AgentsMercaptopurineRetrospective StudiesThioguanineAzathioprineImmunosuppressive AgentsMercaptopurineThioguanine

Identifiers

PMID36136124
PMCPMC9645549
OpenAlexW4296686093

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.