SynthesisEuropean radiology2023
The long-term course of subsolid nodules and predictors of interval growth on chest CT: a systematic review and meta-analysis.
Synthesis in European radiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Risk factors for the growth of ground-glass nodules in the lungs: A systematic review and meta-analysis.Clinics (Sao Paulo, Brazil) · 2025Pooled it
- Assessment of risk factors in persistent subsolid pulmonary nodules based on CT dynamic follow-up.BMC medical imaging · 2026Article
- Clinical Study on the Prevention of High-Risk Pulmonary Nodule Progression With Yifei Sanjie Pill: Protocol for a Multicenter Randomized Controlled Trial.JMIR research protocols · 2026Article
- A narrative review on CT-based evaluation and prediction of lung nodule growth: current status and future directions.Translational lung cancer research · 2026Review
- SGLT2 inhibitor use reduces progression and surgical intervention of persistent pulmonary nodules.Lung cancer (Amsterdam, Netherlands) · 2026Article
- Narrative review: the research advances of artificial intelligence in the prediction of pulmonary nodule growth.Journal of thoracic disease · 2026Review
- [Expert Consensus on Shared Decision-making in the Diagnosis and Treatment of Ground-glass Opacity-featured Lung Adenocarcinoma].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2026Article
- Correlation between CT growth patterns and invasiveness progression in neoplastic subcentimeter sub-solid nodules.Annals of medicine · 2025Article
- Longitudinal variability of CT imaging features for predicting pulmonary nodule invasiveness: A multicenter study.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2025Article
- Natural course of lung adenocarcinoma manifesting as ground-glass nodules: invasiveness assessment based on growth evaluation.Translational lung cancer research · 2025Article
- Screening for Lung Cancer, Overdiagnosis, and Healthcare Utilization: A Nationwide Population-Based Study.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2025Article
- Low-Malignant-Potential Adenocarcinoma: A Histological Category with a Significantly Better Prognosis than Other Solid Adenocarcinomas at IA Stage.Current oncology (Toronto, Ont.) · 2025Article
- Prognosis of surgically resected clinical stage 1A non-small cell lung cancers manifesting as a subsolid nodule on computed tomography including pure ground glass nodules.The Cochrane database of systematic reviews · 2025Article
- Progressive changes in non-neoplastic ground-glass nodules on follow-up computed tomography (CT).Quantitative imaging in medicine and surgery · 2024Article
- Surveillance of subsolid nodules avoids unnecessary resections in lung cancer screening: long-term results of the prospective BioMILD trial.ERJ open research · 2024Article
- Establishing and validation of the VBV score for assessing Lung ground-glass nodules based on high-resolution computed tomography.Journal of cardiothoracic surgery · 2024Article
- Growth assessment of pure ground-glass nodules on CT: comparison of density and size measurement methods.Journal of cancer research and clinical oncology · 2023Article
- Managing Persistent Subsolid Nodules in Lung Cancer: Education, Decision Making, and Impact of Interval Growth Patterns.Diagnostics (Basel, Switzerland) · 2023Review
- Long-term follow-up of persistent pulmonary subsolid nodules: Natural course of pure, heterogeneous, and real part-solid ground-glass nodules.Thoracic cancer · 2023Article
- Baseline whole-lung CT features deriving from deep learning and radiomics: prediction of benign and malignant pulmonary ground-glass nodules.Frontiers in oncology · 2023Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
objectivesTo calculate the pooled incidence of interval growth after long-term follow-up and identify predictors of interval growth in subsolid nodules (SSNs) on chest CT.
methodsA search of MEDLINE (PubMed), Cochrane Library, Web of Science Core Collection, and Embase was performed on November 08, 2021, for relevant studies. Patient information, CT scanner, and SSN follow-up information were extracted from each included study. A random-effects model was applied along with subgroup and meta-regression analyses. Study quality was assessed by the Newcastle-Ottawa scale, and publication bias was assessed by Egger's test.
resultsOf the 6802 retrieved articles, 16 articles were included and analyzed, providing a total of 2898 available SSNs. The pooled incidence of growth in the 2898 SSNs was 22% (95% confidence interval [CI], 15-29%). The pooled incidence of growth in the subgroup analysis of pure ground-glass nodules was 26% (95% CI: 12-39%). The incidence of SSN growth after 2 or more years of stability was only 5% (95% CI: 3-7%). An initially large SSN size was found to be the most frequent risk factor affecting the incidence of SSN growth and the time of growth.
conclusionsThe pooled incidence of SSN growth was as high as 22%, with a 26% incidence reported for pure ground-glass nodules. Although the incidence of growth was only 5% after 2 or more years of stability, long-term follow-up is needed in certain cases. Moreover, the initial size of the SSN was the most frequent risk factor for growth. KEY POINTS: • Based on a meta-analysis of 2898 available subsolid nodules in the literature, the pooled incidence of growth was 22% for all subsolid nodules and 26% for pure ground-glass nodules. • After 2 or more years of stability on follow-up CT, the pooled incidence of subsolid nodule growth was only 5%. • Given the incidence of subsolid nodule growth, management of these lesions with long-term follow-up is preferred.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.