Evidence map›Paper›PMID 36136071›Full record

ArticlePathophysiology : the official journal of the International Society for Pathophysiology2022

Dysregulated Sulfide Metabolism in Multiple Sclerosis: Serum and Vascular Endothelial Inflammatory Responses.

Pooja Veerareddy, Nhi Dao, Jungmi W Yun, Karen Y Stokes, Elizabeth Disbrow, Christopher G Kevil, Urska Cvek, Marjan Trutschl, Philip Kilgore, Murali Ramanathan and 2 more

Open access · goldAbstract read
In one paragraph

Article in Pathophysiology : the official journal of the International Society for Pathophysiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Pooja VeerareddyDepartment of Molecular and Cellular Physiology, LSU Health Shreveport, Shreveport, LA 71103, USA.ORCID 0000-0001-9545-3616
Nhi DaoDepartment of Molecular and Cellular Physiology, LSU Health Shreveport, Shreveport, LA 71103, USA.
Jungmi W YunDepartment of Molecular and Cellular Physiology, LSU Health Shreveport, Shreveport, LA 71103, USA.
Karen Y StokesDepartment of Molecular and Cellular Physiology, LSU Health Shreveport, Shreveport, LA 71103, USA.
Elizabeth DisbrowCenter for Brain Health, LSU Health Shreveport, Shreveport, LA 71130, USA.
Christopher G KevilDepartment of Molecular and Cellular Physiology, LSU Health Shreveport, Shreveport, LA 71103, USA.
Urska CvekDepartment of Computer Science, LSU-Shreveport, Shreveport, LA 71115, USA.ORCID 0000-0003-2042-6415
Marjan TrutschlDepartment of Computer Science, LSU-Shreveport, Shreveport, LA 71115, USA.
Philip KilgoreDepartment of Computer Science, LSU-Shreveport, Shreveport, LA 71115, USA.
Murali RamanathanDepartment of Pharmaceutical Sciences, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14203, USA.
Robert ZivadinovDepartment of Pharmaceutical Sciences, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, NY 14203, USA.ORCID 0000-0002-7799-1485
Jonathan S AlexanderDepartment of Molecular and Cellular Physiology, LSU Health Shreveport, Shreveport, LA 71103, USA.ORCID 0000-0001-6975-3711
Louisiana State University Health Sciences Center Shreveport · USLouisiana State University in Shreveport · USUniversity at Buffalo, State University of New York · US

Funding

Tracking & Evaluation CoreU54GM104940 · NIGMS · LSU PENNINGTON BIOMEDICAL RESEARCH CTR · PI JUDD E SHELLITO · 2012 to 2026
$69.1M
STABILITY' (symptomatic review during biologic therapy) Review in Inflammatory Bowel DiseaseP20GM103424 · NIGMS · LOUISIANA STATE UNIV A&M COL BATON ROUGE · PI Seetharama D Jois · 2012 to 2026
$57.4M
Stress Exacerbates Myocardial Ischemic Injury by Blocking Estrogen's Antidoxidant Protection in the Female HeartP20GM121307 · NIGMS · LOUISIANA STATE UNIV HSC SHREVEPORT · PI Christopher G Kevil · 2018 to 2026
$23.6M
NIGMS NIH HHS P20 GM103424NIGMS NIH HHS P20GM103424NIGMS NIH HHS P20 GM121307NIGMS NIH HHS P20GM121307NIGMS NIH HHS U54 GM104940
6 · The paper itself

Abstract

Multiple sclerosis (MS) is a leading cause of neurodegenerative disability in younger individuals. When diagnosed early, MS can be managed more effectively, stabilizing clinical symptoms and delaying disease progression. The identification of specific serum biomarkers for early-stage MS could facilitate more successful treatment of this condition. Because MS is an inflammatory disease, we assessed changes in enzymes of the endothelial hydrogen sulfide (H

Indexed as

biomarkersbrain endothelial cellsmicroparticlesMS serum samplesmultiple sclerosis

Identifiers

PMID36136071
PMCPMC9502521
OpenAlexW4296349270

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.