ArticleJournal of applied physiology (Bethesda, Md. : 1985)2022
Neonatal intermittent hypoxia persistently impairs lung vascular development and induces long-term lung mitochondrial DNA damage.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 9 citations in OpenAlex.
- Lifelong hypoxia produces multigenerational developmental lung disease and pulmonary hypertension in mice.American journal of physiology. Lung cellular and molecular physiology · 2026Article
- Intermittent hypoxemia metrics enhance bronchopulmonary dysplasia severity predictions in extremely low gestational age newborns.Pediatric research · 2026Article
- Oxidant Stress, Hyperoxia/Hypoxia and Neonatal Respiratory Disorders.Antioxidants (Basel, Switzerland) · 2025Review
- Prolonged Postnatal Hypoxia Impairs Lung Development and Causes Severe Pulmonary Hypertension in Mice.Journal of the American Heart Association · 2025Article
- The Impact of Antenatal and Postnatal Factors on the Development of the Pulmonary Microvasculature in Preterm Infants.Children (Basel, Switzerland) · 2025Article
- The Plant Hormone Indole-3-Acetic Acid Helps the Endothelial Barrier Seal after Lung Injury.American journal of respiratory cell and molecular biology · 2024Article
- Developmental PFOS exposure alters lung inflammation and barrier integrity in juvenile mice.Toxicological sciences : an official journal of the Society of Toxicology · 2024Article
- Article
- Hedgehog and Platelet-derived Growth Factor Collaborate to Guide Fibroblasts during Alveolarization.American journal of respiratory cell and molecular biology · 2023Article
- Can Intermittent Hypoxemia Help Detect Pulmonary Hypertension in High-risk Preemies?American journal of respiratory and critical care medicine · 2023Article
- Antenatal and Postnatal Sequelae of Oxidative Stress in Preterm Infants: A Narrative Review Targeting Pathophysiological Mechanisms.Antioxidants (Basel, Switzerland) · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
16 authors at 2 institutions in 1 country.
Funding
Abstract
Adults born preterm have an increased risk of pulmonary vascular disease. Extreme preterm infants often require supplemental oxygen but they also exhibit frequent intermittent hypoxemic episodes (IH). Here, we test the hypothesis that neonatal IH induces lung endothelial cell mitochondrial DNA (mitDNA) damage and contributes to long-term pulmonary vascular disease and pulmonary hypertension (PH). Newborn C57BL/6J mice were assigned to the following groups:
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.