Evidence map›Paper›PMID 36135952›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2022

Thyrotropin-releasing hormone analog as a stable upper airway-preferring respiratory stimulant with arousal properties.

Wen-Ying Liu, Raina Ladha, Hattie Liu, Richard L Horner

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. New Efforts to Demonstrate the Successful Use of TRH as a Therapeutic Agent.International journal of molecular sciences · 2023
    Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Wen-Ying LiuDepartment of Physiology, University of Toronto, Toronto, Ontario, Canada.
Raina LadhaDepartment of Physiology, University of Toronto, Toronto, Ontario, Canada.
Hattie LiuDepartment of Physiology, University of Toronto, Toronto, Ontario, Canada.
Richard L HornerDepartment of Physiology, University of Toronto, Toronto, Ontario, Canada.ORCID 0000-0002-5593-2548
University of Toronto · CA

Funding

Canada Research Chairs (Chaires de recherche du Canada) 950-229813Gouvernement du Canada | Canadian Institutes of Health Research (IRSC) PJT-153243Gouvernement du Canada | Canadian Institutes of Health Research (IRSC) PJT-180288National Sanitarium Association (NSA) 497478
6 · The paper itself

Abstract

Taltirelin is a stable, brain-penetrating thyrotropin-releasing hormone (TRH) analog with minimal endocrine activity and potential respiratory stimulant properties. Taltirelin's receptor target shows high differential expression at the hypoglossal motor nucleus, and local taltirelin microperfusion into the hypoglossal motor nucleus causes sustained tongue motor activation compared with the transient activating effects of TRH itself. Here, we performed a randomized, within-subject, repeated-measures design over six separate study days (separated by at least 72 h) in chronically instrumented male (

Indexed as

Respiratory System AgentsSleep Apnea, ObstructiveTrazodoneAnimalsArousalFemaleMaleRatsSleepThyrotropin-Releasing HormoneRespiratory System AgentsThyrotropin-Releasing HormoneTrazodonegenioglossusobstructive sleep apneasleeptaltirelinthyrotropin-releasing hormone

Identifiers

PMID36135952
PMCPMC9602822
OpenAlexW4296658764

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.