Evidence map›Paper›PMID 36135884›Full record

ArticleMembranes2022

Effect of Modified Levopimaric Acid Diene Adducts on Mitochondrial and Liposome Membranes.

Mikhail V Dubinin, Vyacheslav A Sharapov, Alena A Semenova, Lyudmila V Parfenova, Anna I Ilzorkina, Ekaterina I Khoroshavina, Natalia V Belosludtseva, Sergey V Gudkov, Konstantin N Belosludtsev

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Membranes, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Mikhail V DubininDepartment of Biochemistry, Cell Biology and Microbiology, Mari State University, pl. Lenina 1, 424001 Yoshkar-Ola, Russia.ORCID 0000-0002-7453-3390
Vyacheslav A SharapovDepartment of Biochemistry, Cell Biology and Microbiology, Mari State University, pl. Lenina 1, 424001 Yoshkar-Ola, Russia.
Alena A SemenovaDepartment of Biochemistry, Cell Biology and Microbiology, Mari State University, pl. Lenina 1, 424001 Yoshkar-Ola, Russia.ORCID 0000-0002-4258-9015
Lyudmila V ParfenovaInstitute of Petrochemistry and Catalysis, Ufa Federal Research Center, Russian Academy of Sciences, Prospekt Oktyabrya 141, 450075 Ufa, Russia.ORCID 0000-0003-2816-2178
Anna I IlzorkinaInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Institutskaya 3, 142290 Pushchino, Russia.
Ekaterina I KhoroshavinaDepartment of Biochemistry, Cell Biology and Microbiology, Mari State University, pl. Lenina 1, 424001 Yoshkar-Ola, Russia.
Natalia V BelosludtsevaInstitute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Institutskaya 3, 142290 Pushchino, Russia.ORCID 0000-0001-5707-6557
Sergey V GudkovProkhorov General Physics Institute of the Russian Academy of Sciences, Vavilov St. 38, 119991 Moscow, Russia.ORCID 0000-0002-8814-6906
Konstantin N BelosludtsevDepartment of Biochemistry, Cell Biology and Microbiology, Mari State University, pl. Lenina 1, 424001 Yoshkar-Ola, Russia.ORCID 0000-0001-5392-7035
Mari State University · RUInstitute of Theoretical and Experimental Biophysics · RUProkhorov General Physics Institute · RUUfa Institute of Chemistry · RU

Funding

Federal Program FMRS-2022-0081Russian Foundation for Basic Research 20-015-00124
6 · The paper itself

Abstract

This paper demonstrates the membranotropic effect of modified levopimaric acid diene adducts on liver mitochondria and lecithin liposomes. We found that the derivatives dose-dependently reduced the efficiency of oxidative phosphorylation of mitochondria due to inhibition of the activity of complexes III and IV of the respiratory chain and protonophore action. This was accompanied by a decrease in the membrane potential in the case of organelle energization both by glutamate/malate (complex I substrates) and succinate (complex II substrate). Compounds

Indexed as

levopimaric acid diene adductsliposomesmembrane permeabilitymitochondriaoxidative phosphorylationROS

Identifiers

PMID36135884
PMCPMC9503697
OpenAlexW4296118051

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.