Stimulation of Neurite Outgrowth in Cerebrocortical Neurons by Sodium Channel Activator Brevetoxin-2 Requires Both N-Methyl-D-aspartate Receptor 2B (GluN2B) and p21 Protein (Cdc42/Rac)-Activated Kinase 1 (PAK1).

Suneet Mehrotra, Marsha L Pierce, Shashank M Dravid, Thomas F Murray

Open access · goldAbstract read

In one paragraph

Article in Marine drugs, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.4field-weighted citation impact, top 47% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

Marine Pharmacology in 2022-2023: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis and Antiviral Activities, Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action.Marine drugs · 2026
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Suneet MehrotraDepartment of Pharmacology and Neuroscience, School of Medicine, Creighton University, Omaha, NE 68178, USA.ORCID 0000-0003-1756-5254

Marsha L PierceDepartment of Pharmacology and Neuroscience, School of Medicine, Creighton University, Omaha, NE 68178, USA.ORCID 0000-0002-7265-0104

Shashank M DravidDepartment of Pharmacology and Neuroscience, School of Medicine, Creighton University, Omaha, NE 68178, USA.

Thomas F MurrayDepartment of Pharmacology and Neuroscience, School of Medicine, Creighton University, Omaha, NE 68178, USA.ORCID 0000-0001-8521-4507

Creighton University · US

Funding

Neurotoxins from Marine Algae and CyanobacteriaR01NS053398 · NINDS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GERWICK, WILLIAM HENRY, MURRAY, THOMAS F · 2005 to 2015

$4.3M

National Institute of Health NIH 2RO1 NS0533398-11 TFMNINDS NIH HHS R01 NS053398

6 · The paper itself

Abstract

N-methyl-D-aspartate (NMDA) receptors play a critical role in activity-dependent dendritic arborization, spinogenesis, and synapse formation by stimulating calcium-dependent signaling pathways. Previously, we have shown that brevetoxin 2 (PbTx-2), a voltage-gated sodium channel (VGSC) activator, produces a concentration-dependent increase in intracellular sodium [Na

Indexed as

Neuronsp21-Activated KinasesReceptors, N-Methyl-D-AspartateActin Depolymerizing FactorsActinsAnimalsCalciumMarine ToxinsMiceNeuronal OutgrowthN-MethylaspartateOxocinsPolyether Toxinsrho GTP-Binding ProteinsRNA, Small InterferingSodiumActin Depolymerizing FactorsActinsbrevetoxin 2CalciumMarine ToxinsN-MethylaspartateNR2B NMDA receptorOxocinsp21-Activated KinasesPak1 protein, mousePolyether ToxinsPtychodiscus brevis T2 toxinReceptors, N-Methyl-D-Aspartaterho GTP-Binding ProteinsRNA, Small InterferingSodiumSodium Channel AgonistsVoltage-Gated Sodium Channelsbrevetoxin 2 (PbTx-2)dendritic arborizationL-type calcium channelminiature excitatory post-synatpic currents (mEPSCs)neurite outgrowthN-methyl-D-aspartate (NMDA) receptor 2b (GluN2B)p21 protein (Cdc42/Rac1)-activated kinase 1 (PAK1)sodium–calcium exchangervoltage-gated calcium channel (VGCC)voltage-gated sodium channel (VGSC)

Identifiers

PMID36135748

DOI10.3390/md20090559

PMCPMC9504648

OpenAlexW4294307808

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.