Evidence map›Paper›PMID 36135565›Full record

ArticleJournal of functional biomaterials2022

The Anticancer Efficacy of Thiourea-Mediated Reduced Graphene Oxide Nanosheets against Human Colon Cancer Cells (HT-29).

Babu Vimalanathan, J Judith Vijaya, B Carmel Jeeva Mary, Savarimuthu Ignacimuthu, Magesh Daniel, Ramasamy Jayavel, Mohamed Bououdina, Stefano Bellucci

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of functional biomaterials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Babu VimalanathanCrystal Growth Centre, Anna University, Chennai 600025, India.
J Judith VijayaCatalysis and Nanomaterials Research Laboratory, Department of Chemistry, Loyola College, Chennai 600034, India.ORCID 0000-0002-7219-3935
B Carmel Jeeva MaryCatalysis and Nanomaterials Research Laboratory, Department of Chemistry, Loyola College, Chennai 600034, India.
Savarimuthu IgnacimuthuXavier Research Foundation, St. Xavier's College, Palayamkottai, Thirunelveli 627002, India.
Magesh DanielDepartment of Zoology, Loyola College, Chennai 600034, India.
Ramasamy JayavelCrystal Growth Centre, Anna University, Chennai 600025, India.
Mohamed BououdinaDepartment of Mathematics and Sciences, Faculty of Humanities and Sciences, Prince Sultan University, Riyadh 122001, Saudi Arabia.ORCID 0000-0001-8770-7129
Stefano BellucciINFN-Laboratori Nazionali di Frascati, Via E. Fermi 54, 00044 Frascati, Italy.ORCID 0000-0003-0326-6368
Anna University, Chennai · INIstituto Nazionale di Fisica Nucleare, Laboratori Nazionali di Frascati · ITPrince Sultan University · SASt. Xavier's College (Autonomous)

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The current research focuses on the fabrication of water-soluble, reduced graphene oxide (rGO) employing thiourea (T) using a simple cost-effective method, and subsequently examining its anticancer characteristics. The cytotoxicity caused by graphene oxide (GO) and T-rGO is investigated in detail. Biological results reveal a concentration-dependent toxicity of GO and T-rGO in human colon cancer cells HT-29. A decrease in cell viability alongside DNA fragmentation is observed. Flow cytometry analysis confirms the cytotoxic effects. The novelty in this work is the use of raw graphite powder, and oxidants such as KMNO

Indexed as

colon cancer cellsDNA fragmentationflow cytometry analysisreduced graphene oxidescanning electron microscopythiourea

Identifiers

PMID36135565
PMCPMC9502518
OpenAlexW4293759807

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.