Evidence map›Paper›PMID 36135367›Full record

ArticlemBio2022

Salmonella enterica Infections Are Disrupted by Two Small Molecules That Accumulate within Phagosomes and Differentially Damage Bacterial Inner Membranes.

Joseph A Villanueva, Amy L Crooks, Toni A Nagy, Joaquin L J Quintana, Zachary D Dalebroux, Corrella S Detweiler

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Joseph A VillanuevaDepartment of Molecular, Cellular, and Developmental Biology, University of Colorado Bouldergrid.266190.a, Boulder, Colorado, USA.
Amy L CrooksDepartment of Molecular, Cellular, and Developmental Biology, University of Colorado Bouldergrid.266190.a, Boulder, Colorado, USA.
Toni A NagyDepartment of Molecular, Cellular, and Developmental Biology, University of Colorado Bouldergrid.266190.a, Boulder, Colorado, USA.
Joaquin L J QuintanaDepartment of Molecular, Cellular, and Developmental Biology, University of Colorado Bouldergrid.266190.a, Boulder, Colorado, USA.
Zachary D DalebrouxDepartment of Microbiology and Immunology, University of Oklahoma Health Sciences Centergrid.266902.9, Oklahoma City, Oklahoma, USA.ORCID 0000-0001-9348-2894
Corrella S DetweilerDepartment of Molecular, Cellular, and Developmental Biology, University of Colorado Bouldergrid.266190.a, Boulder, Colorado, USA.ORCID 0000-0002-7783-0876
University of Colorado Boulder · USUniversity of Oklahoma Health Sciences Center · US

Funding

Mechanisms of PbgA involvement in Salmonella Typhimurium lipid homeostasis for bacterial pathogenesisR01AI139248 · NIAID · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI DALEBROUX, ZACHARY DAVID · 2018 to 2022
$1.8M
A Novel Screen for Antibacterials that Are Non-Toxic to MammalsR33AI121365 · NIAID · UNIVERSITY OF COLORADO · PI DETWEILER, CORRELLA S, WANG, XIANG · 2018 to 2020
$1.4M
A Small Molecule That Blocks Salmonella Replication in MacrophagesR21AI151979 · NIAID · UNIVERSITY OF COLORADO · PI DETWEILER, CORRELLA S · 2021 to 2022
$424k
A Novel Screen for Antibacterials that Are Non-Toxic to MammalsR21AI121365 · NIAID · UNIVERSITY OF COLORADO · PI DETWEILER, CORRELLA S, WANG, XIANG · 2016 to 2017
$412k
NIAID NIH HHS R01 AI139248NIAID NIH HHS R21 AI121365NIAID NIH HHS R21 AI151979NIAID NIH HHS R33 AI121365
6 · The paper itself

Abstract

Gram-negative bacteria have a robust cell envelope that excludes or expels many antimicrobial agents. However, during infection, host soluble innate immune factors permeabilize the bacterial outer membrane. We identified two small molecules that exploit outer membrane damage to access the bacterial cell. In standard microbiological media, neither compound inhibited bacterial growth nor permeabilized bacterial outer membranes. In contrast, at micromolar concentrations, JAV1 and JAV2 enabled the killing of an intracellular human pathogen, Salmonella enterica serovar Typhimurium.

Indexed as

CardiolipinsSalmonella InfectionsAminesAnimalsAnti-Bacterial AgentsEscherichia coliGlycerophospholipidsHumansLipopolysaccharidesLiposomesMammalsPhagosomesSalmonella typhimuriumAminesAnti-Bacterial AgentsCardiolipinsGlycerophospholipidsLipopolysaccharidesLiposomesamine substitutedantibacterialanti-infectiveGalleria mellonellainner membraneintracellular pathogenintravesicular pathogenlysosomal trappingmacrophageSalmonella enterica

Identifiers

PMID36135367
PMCPMC9601186
OpenAlexW4296646540

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.