Evidence map›Paper›PMID 36135256›Full record

ArticleGels (Basel, Switzerland)2022

In Vivo Effect of Resveratrol-Cellulose Aerogel Drug Delivery System to Relieve Inflammation on Sports Osteoarthritis.

Ningxin Cui, Zhen Xu, Xinyu Zhao, Meng Yuan, Leiyu Pan, Tianfeng Lu, Ai Du, Lili Qin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gels (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Ningxin CuiSports and Health Research Center, Department of Physical Education, Tongji University, Shanghai 200092, China.
Zhen XuSports and Health Research Center, Department of Physical Education, Tongji University, Shanghai 200092, China.
Xinyu ZhaoSports and Health Research Center, Department of Physical Education, Tongji University, Shanghai 200092, China.
Meng YuanSports and Health Research Center, Department of Physical Education, Tongji University, Shanghai 200092, China.
Leiyu PanSports and Health Research Center, Department of Physical Education, Tongji University, Shanghai 200092, China.
Tianfeng LuSports and Health Research Center, Department of Physical Education, Tongji University, Shanghai 200092, China.
Ai DuSchool of Physics Science and Engineering, Tongji University, Shanghai 200092, China.ORCID 0000-0002-6113-6185
Lili QinSports and Health Research Center, Department of Physical Education, Tongji University, Shanghai 200092, China.
Tongji University · CN

Funding

National Natural Science Foundation of China No. 31771313the National Key Research and Development Program of China 2017YFA0204600
6 · The paper itself

Abstract

Resveratrol (Res) is a plant extract with strong anti-inflammatory, antioxidant and anti-aging biological activities. However, Res is limited by its disadvantages, such as poor solubility, rapid metabolism and low bioavailability. In this study, the Resveratrol-loaded TEMPO-oxidized cellulose aerogel (RLTA) drug delivery system was prepared by the method of "dissolution-freeze-drying" and characterized by a series of analysis. Then the blood biochemical indexes and HE staining were measured and analyzed in animal experiments. The in vivo results showed that RLTA can decrease the levels of TNF-α and IL-6 inflammatory factors in the synovial fluid. Furthermore, the molecular mechanism was investigated through the analysis of silent information regulator 2 homolog 1 (Sirt1) protein expression, which suggested that RLTA could upregulate the expression of Sirt1 and mediate the P38 signaling pathway, thereby inhibiting the expression of COX-2 and MMP13 which can suppress the levels of IL-6 and TNF-α inflammatory factor. These results reveal that cellulose aerogel is a promising candidate for drug delivery and RLTA has great potential application for the treatment of sports osteoarthritis.

Indexed as

anti-inflammatorycellulose aerogelosteoarthritisresveratrol

Identifiers

PMID36135256
PMCPMC9498302
OpenAlexW4293524910

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.