ArticleBioengineering (Basel, Switzerland)2022
Differential Sensitization of Muscle versus Fascia in Individuals with Low Back Pain.
Article in Bioengineering (Basel, Switzerland), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 9 citations in OpenAlex.
- Fascia as a Functional System in Health and Disease: From Fundamental Biology to Assessment and Targeted Interventions.International journal of molecular sciences · 2026Review
- Editorial: Physical Examination and Rehabilitation of Fasciae and Muscles in Sports Injuries.Bioengineering (Basel, Switzerland) · 2025Article
- Effect of manual handling weight for lifting and carrying on the severity of acute occupational low back pain.International archives of occupational and environmental health · 2025Article
- Effects of different types of core training on pain and functional status in patients with chronic nonspecific low back pain: a systematic review and meta-analysis.Frontiers in physiology · 2025Review
- MRI T2 mapping and shear wave elastography for identifying main pain generator in delayed-onset muscle soreness: muscle or fascia?Insights into imaging · 2024Article
- Advancing musculoskeletal diagnosis and therapy: a comprehensive review of trigger point theory and muscle pain patterns.Frontiers in medicine · 2024Article
- Summaries of the Padua symposium on myofascial pain, fibromyalgia, and fascial pain disorders, June 2023,European journal of translational myology · 2023Article
- Global Status and Future Trends of Fascia and Pain Research in 2013-2022: Bibliometric Analysis Based on CiteSpace and VOSviewer.Journal of pain research · 2023Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Muscles and the deep fascia surrounding them have been suggested to play an important role in various musculoskeletal pain conditions including low back pain. Both have been shown to host rich nociceptive innervation and to undergo changes in individuals with chronic pain. However, evidence for the respective contribution of muscle and fascia sensitization in humans with myofascial pain syndrome is lacking. Here, we studied the sensitization of muscle and fascia in individuals with myofascial low back pain. Twenty individuals with acute (5) and chronic (15) myofascial low back pain of the quadratus lumborum muscle and a matched control group of twenty healthy individuals were recruited and clinically evaluated. All participants underwent ultrasound-guided needling of their subcutaneous tissue, deep fascia and quadratus lumborum muscle. Reported pain intensity and episodes of muscle twitching were recorded and analyzed. Among pain patients, both muscles and deep fascia demonstrated pain hypersensitivity, but muscles were significantly more sensitized than the deep fascia. No difference between acute- or chronic-pain patients was observed. Results of this study suggest that while both deep fascia and muscle show pain sensitization in both early and chronic stages of low back pain, muscles are more sensitized than fascia.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.