ArticleJournal of diabetes investigation2022
Neurodevelopmental delay up to the age of 4 years in infants born to women with gestational diabetes mellitus: The Japan Environment and Children's Study.
Article in Journal of diabetes investigation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 25 citations in OpenAlex.
- Physical health and neurodevelopmental outcome in 7-year-old children whose mothers were at risk of gestational diabetes mellitus: a follow-up of a randomized controlled trial.Acta obstetricia et gynecologica Scandinavica · 2023Trial
- Neurodevelopmental outcomes of children born to diabetic mothers in the Qatari population: a retrospective study.BMJ paediatrics open · 2026Article
- Sex-specific association between maternal integrative endocrine and metabolic status during pregnancy and preschoolers' emotional-behavioral development: A birth cohort study.European child & adolescent psychiatry · 2026Article
- Evaluating the effects of maternal diabetes on early infant neurodevelopment with a novel combination of four neurodevelopmental tools.Early human development · 2026Article
- Fetal sex-specific differences in the placental transcriptome of gestational diabetes.Scientific reports · 2026Observational
- Measuring child development at the 2-2½-year health and development review in England: a rapid scoping review of available tools.BMJ open · 2026Article
- GDM-Related Neurodevelopmental and Neuropsychiatric Disorders in the Mothers and Their Progeny, and the Underlying Mechanisms.Journal of personalized medicine · 2026Review
- Maternal Pre-Pregnancy Glycemic Status and Developmental Outcomes in Korean Children Aged 18-36 Months: A Nationwide Population-Based Cohort Study (2014-2021).Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Fetal behavior as a window to later gross motor function: a 10-year follow-up of children prenatally exposed to gestational diabetes mellitus.Frontiers in clinical diabetes and healthcare · 2026Article
- Effect of gestational diabetes on neurodevelopment outcome of the offsprings- Ma'an shan birth cohort study.BMC pediatrics · 2025Article
- Maternal Fasting Plasma Glucose Level in Early Gestation and Developmental Delay in 2-year-old Children.The Journal of clinical endocrinology and metabolism · 2025Article
- Low glucose challenge test result as a potential risk factor for delays in early child development: the Japan environment and children's study.Journal of diabetes and metabolic disorders · 2025Article
- Impact of tea and coffee consumption during pregnancy on children's cognitive development.Scientific reports · 2025Article
- Multi-omics integration analysis and association study reveal the potential of ADIPOQ function in gestational diabetes mellitus.Nutrition & diabetes · 2025Article
- Dietary glycemic index and load during pregnancy and offspring behavioral outcomes: exploring sex differences.European journal of pediatrics · 2025Observational
- A Review of the Impact of Gestational Diabetes on Fetal Brain Development: An Update on Neurosonographic Markers During the Last Decade.Life (Basel, Switzerland) · 2025Review
- Neurodevelopmental trajectories in well-controlled gestational diabetes mellitus offspring: No differences were found at the 6- and 12-month assessments.Frontiers in endocrinology · 2025Article
- Influence of preterm birth on the association between gestational diabetes mellitus and childhood developmental vulnerability: a causal mediation analysis.World journal of pediatrics : WJP · 2024Article
- The impact of maternal diabetes on the future health and neurodevelopment of the offspring: a review of the evidence.Frontiers in endocrinology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 6 institutions in 2 countries.
Funding
Abstract
AIMS/
introductionThis study aimed to investigate the neurodevelopment of infants born to women with gestational diabetes mellitus (GDM). MATERIALS AND
methodsData from the National Birth Cohort in the Japan Environment and Children's Study from 2011 to 2014 (n = 81,705) were used. Japan uses the GDM guidelines of the International Association of Diabetes and Pregnancy Study Groups. The Japanese translation of the Ages and Stages Questionnaires, third Edition, was used to assess neurodevelopment in the following domains: communication skills, gross motor skills, fine motor skills, problem-solving ability, and personal and social skills. The survey was carried out every 6 months from the age of 6 months to 4 years (total of eight times). Generalized estimating equations were used to evaluate the association between maternal GDM and neurodevelopmental delay based on odds ratios (ORs) and 95% confidence intervals (95% CIs).
resultsNeurodevelopmental delays, particularly in problem-solving ability, fine motor skills, and personal and social skills, were significantly higher in infants born to women with GDM than in those born to women without GDM (adjusted OR 1.24, 95% CI 1.12-1.36; adjusted OR 1.15, 95% CI 1.03-1.27; and adjusted OR 1.18, 95% CI 1.04-1.33). Furthermore, stratification showed no significant increase in the adjusted ORs (95% CIs) of girls.
conclusionsNeurodevelopment was significantly delayed up to 4 years-of-age among boys born to women with GDM.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.