Evidence map›Paper›PMID 36134886›Full record

ArticleeLife2022

Variable paralog expression underlies phenotype variation.

Raisa Bailon-Zambrano, Juliana Sucharov, Abigail Mumme-Monheit, Matthew Murry, Amanda Stenzel, Anthony T Pulvino, Jennyfer M Mitchell, Kathryn L Colborn, James T Nichols

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Early ultraviolet exposure disrupts late dorsal fin skeletal development in zebrafish.Developmental dynamics : an official publication of the American Association of Anatomists · 2026
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  13. Distinct and redundant roles for zebrafishFrontiers in endocrinology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Raisa Bailon-Zambrano *Department of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, United States.ORCID 0000-0002-5848-3952
Juliana Sucharov *Department of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, United States.
Abigail Mumme-MonheitDepartment of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, United States.ORCID 0000-0003-0090-1418
Matthew MurryDepartment of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, United States.
Amanda StenzelDepartment of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, United States.
Anthony T PulvinoDepartment of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, United States.
Jennyfer M MitchellDepartment of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, United States.ORCID 0000-0003-4222-5235
Kathryn L ColbornDepartment of Surgery, University of Colorado Anschutz Medical Campus, Aurora, United States.
James T NicholsDepartment of Craniofacial Biology, University of Colorado Anschutz Medical Campus, Aurora, United States.ORCID 0000-0002-7263-1704
University of Colorado Anschutz Medical Campus · US

Funding

Mechanisms of Developmental BufferingR01DE029193 · NIDCR · UNIVERSITY OF COLORADO DENVER · PI James Tucker Nichols · 2021 to 2026
$2.6M
Using Zebrafish as an in vivo Model for Frontonasal Development and DiseaseF32DE029995 · NIDCR · UNIVERSITY OF COLORADO DENVER · PI MITCHELL, JENNYFER MORA · 2020 to 2022
$227k
NIDCR NIH HHS F32 DE029995NIDCR NIH HHS R01 DE029193
6 · The paper itself

Abstract

Human faces are variable; we look different from one another. Craniofacial disorders further increase facial variation. To understand craniofacial variation and how it can be buffered, we analyzed the zebrafish

Indexed as

MEF2 Transcription FactorsZebrafishZebrafish ProteinsAnimalsBiological Variation, PopulationHumansPhenotypeTranscription FactorsMef2ca protein, zebrafishMEF2 Transcription FactorsTranscription FactorsZebrafish Proteinscompensationcraniofacial developmentdevelopmental biologydevelopmental bufferinggene duplicationgeneticsgenomicsparalogsrobustnesssubfunctionalizationvariabilityvestigial expressionzebrafish

Identifiers

PMID36134886
PMCPMC9555865
OpenAlexW4296645300

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.