Evidence map›Paper›PMID 36134743›Full record

ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2023

Association of Treated and Untreated Chronic Hepatitis C With the Incidence of Active Tuberculosis Disease: A Population-Based Cohort Study.

Davit Baliashvili, Henry M Blumberg, David Benkeser, Russell R Kempker, Shaun Shadaker, Francisco Averhoff, Lia Gvinjilia, Natalia Adamashvili, Matthew Magee, George Kamkamidze and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Host Risk Factors for Tuberculosis.Infectious disorders drug targets · 2025
    Review
  6. Review
  7. Observational
  8. Article
  9. Review
  10. Article
  11. Review
  12. A scoping review on the risk of tuberculosis in specific population groups: can we expand the World Health Organization recommendations?European respiratory review : an official journal of the European Respiratory Society · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 2 countries.

Davit BaliashviliDepartment of Epidemiology, Emory University Rollins School of Public Health, Atlanta, Georgia, USA.ORCID 0000-0001-8390-3325
Henry M BlumbergDepartment of Epidemiology, Emory University Rollins School of Public Health, Atlanta, Georgia, USA.
David BenkeserDepartment of Biostatistics and Bioinformatics, Emory University Rollins School of Public Health, Atlanta, Georgia, USA.
Russell R KempkerDivision of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Shaun ShadakerDivision of Viral Hepatitis, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Francisco AverhoffDepartment of Family and Preventive Medicine, Emory University School of Medicine, Atlanta, Georgia, USA.
Lia GvinjiliaEastern Europe and Central Asia Regional Office, Centers for Disease Control and Prevention, Tbilisi, Georgia.
Natalia AdamashviliNational Center for Disease Control and Public Health, Tbilisi, Georgia.
Matthew MageeDepartment of Global Health, Emory University Rollins School of Public Health, Atlanta, Georgia, USA.
George KamkamidzeHealth Research Union and Clinic NeoLab, Tbilisi, Georgia.
Mamuka ZakalashviliClinic "Mrcheveli", Tbilisi, Georgia.
Tengiz TsertsvadzeInfectious Diseases, AIDS and Clinical Immunology Research Center, Tbilisi, Georgia.
Lali SharvadzeClinic "Hepa", Tbilisi, Georgia.
Mamuka ChincharauliNational Center for Tuberculosis and Lung Diseases, Tbilisi, Georgia.
Nestan TukvadzeNational Center for Tuberculosis and Lung Diseases, Tbilisi, Georgia.
Neel R GandhiDepartment of Epidemiology, Emory University Rollins School of Public Health, Atlanta, Georgia, USA.
Emory University · USCenters for Disease Control and Prevention · USNational Center for Tuberculosis and Lung Disease · GEAIDS and Clinical Immunology Research Center · GENational Center for Disease Control and Public Health · GEUniversity of Georgia · GE

Funding

Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Carlos del Rio · 2002 to 2026
$74.0M
Role of antigen-specific T cell responses in the control of TBU19AI111211 · NIAID · EMORY UNIVERSITY · PI BLUMBERG, HENRY M, ERNST, JOEL D. · 2014 to 2020
$20.1M
Emory/Georgia TB Research Advancement Center (TRAC)P30AI168386 · NIAID · EMORY UNIVERSITY · PI Jeffrey M Collins · 2022 to 2026
$5.8M
Emory-Georgia TB Research Training ProgramD43TW007124 · FIC · EMORY UNIVERSITY · PI HENRY M BLUMBERG, Nestani Tukvadze · 2004 to 2026
$4.6M
Mentorship in Patient-Oriented Research in Tuberculosis, HIV and Global HealthK24AI114444 · NIAID · EMORY UNIVERSITY · PI GANDHI, NEEL RAJNIKANT · 2014 to 2023
$1.8M
FIC NIH HHS D43 TW007124Intramural CDC HHS CC999999NIAID NIH HHS K24 AI114444NIAID NIH HHS P30 AI050409NIAID NIH HHS P30 AI168386NIAID NIH HHS U19 AI111211
6 · The paper itself

Abstract

backgroundHepatitis C virus (HCV) infection causes dysregulation and suppression of immune pathways involved in the control of tuberculosis (TB) infection. However, data on the role of chronic hepatitis C as a risk factor for active TB are lacking. We sought to evaluate the association between HCV infection and the development of active TB.

methodsWe conducted a cohort study in Georgia among adults tested for HCV antibodies (January 2015-September 2020) and followed longitudinally for the development of newly diagnosed active TB. Data were obtained from the Georgian national programs of hepatitis C and TB. The exposures of interest were untreated and treated HCV infection. A Cox proportional hazards model was used to calculate adjusted hazard ratios (aHRs).

resultsA total of 1 828 808 adults were included (median follow-up time: 26 months; IQR: 13-39 months). Active TB was diagnosed in 3163 (0.17%) individuals after a median of 6 months follow-up (IQR: 1-18 months). The incidence rate per 100 000 person-years was 296 among persons with untreated HCV infection, 109 among those with treated HCV infection, and 65 among HCV-negative persons. In multivariable analysis, both untreated (aHR = 2.9; 95% CI: 2.4-3.4) and treated (aHR = 1.6; 95% CI: 1.4-2.0) HCV infections were associated with a higher hazard of active TB, compared with HCV-negative persons.

conclusionsAdults with HCV infection, particularly untreated individuals, were at higher risk of developing active TB disease. Screening for latent TB infection and active TB disease should be part of clinical evaluation of people with HCV infection, especially in high-TB-burden areas.

Indexed as

Hepatitis CHepatitis C, ChronicLatent TuberculosisTuberculosisAdultCohort StudiesHepacivirusHumansIncidenceRisk Factorscohorthepatitis Ctuberculosis

Identifiers

PMID36134743
PMCPMC10194043
OpenAlexW4296816595

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.