Evidence map›Paper›PMID 36134673›Full record

ArticlePediatric endocrinology, diabetes, and metabolism2022

Skeletal status in children and adolescents with new-onset type 1 diabetes: a preliminary study based on bone densitometry and quantitative ultrasound.

Francesca Silvestri, Marco Infante, Andrea Fabbri, Carla Ferrara, Giampiero Ferraguti, Francesco Costantino, Elena Ferrari, Enea Bonci, Arianna Turchetti, Claudio Tiberti and 1 more

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Article in Pediatric endocrinology, diabetes, and metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Francesca SilvestriDepartment of Paediatrics, Section of Paediatric Diabetology, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
Marco InfanteDepartment of Systems Medicine, Diabetes Research Institute Federation (DRIF), University of Rome Tor Vergata, Rome, Italy.
Andrea FabbriDepartment of Systems Medicine, Diabetes Research Institute Federation (DRIF), University of Rome Tor Vergata, Rome, Italy.
Carla FerraraDepartment of Public Health and Infectious Diseases, Section Health Statistics, Sapienza University of Rome, Rome, Italy.
Giampiero FerragutiDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Francesco CostantinoDepartment of Paediatrics, Section of Paediatric Diabetology, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
Elena FerrariDepartment of Paediatrics, Section of Paediatric Diabetology, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.
Enea BonciDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Arianna TurchettiDepartment of Paediatrics, Centre for Congenital Osteodystrophy, Sapienza University of Rome, Rome, Italy.
Claudio TibertiDepartment of Experimental Medicine, Sapienza University of Rome, Rome, Italy.
Valeria TrombaDepartment of Paediatrics, Section of Paediatric Diabetology, Policlinico Umberto I, Sapienza University of Rome, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionType 1 diabetes (T1D) represents a risk factor for bone loss and impaired bone quality. MATERIAL AND

methodsWe conducted an exploratory retrospective cross-sectional study involving youths with new-onset T1D, to investigate the relationship between lumbar spine dual-energy X-ray absorptiometry (DXA) and phalangeal quantitative ultrasound (QUS) measurements, along with their correlation with markers of bone turnover, glucose homeostasis, and residual β-cell function.

results17 children and adolescents (8 females) with recent-onset T1D were enrolled into this study. Lumbar spine areal bone mineral density (aBMD) and age-adjusted amplitude-dependent speed of sound (AD-SoS) Z-scores were indicative of low BMD status (≤ -2.0 SD) in 11.7% and 17.6% of participants, respectively. Spearman's correlation analysis revealed significant inverse correlations between AD-SoS values and circulating levels of β-CrossLaps, alkaline phosphatase, and osteocalcin, along with a significant positive correlation between bone transmission time (BTT) values and fasting plasma C-peptide (FCP) levels. There was no statistically significant correlation between DXA-QUS parameters, fasting plasma glucose (FPG), and glycated haemoglobin (HbA1c). Finally, there was a significant positive correlation between lumbar spine aBMD and BTT values.

conclusionsOur study suggests that DXA and/or QUS parameters may be altered in a small proportion of T1D children and adolescents at the disease onset. Additionally, residual β-cell function may represent a protective factor against T1D-related detrimental skeletal changes. Large and long-term prospective studies are needed to confirm these preliminary findings since the present study is limited by the retrospective cross-sectional design and by its small sample size.

Indexed as

Diabetes Mellitus, Type 1Finger PhalangesAbsorptiometry, PhotonAdolescentAlkaline PhosphataseBlood GlucoseBone DensityChildC-PeptideCross-Sectional StudiesFemaleGlycated HemoglobinHumansOsteocalcinRetrospective StudiesAlkaline PhosphataseBlood GlucoseC-PeptideGlycated HemoglobinOsteocalcinbone mineral densitybone qualitydual-energy X-ray absorptiometrynew-onset type 1 diabetesquantitative ultrasound.

Identifiers

PMID36134673
PMCPMC10214978

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