Evidence map›Paper›PMID 36134578›Full record

ArticleCirculation research2022

LncRNA PSR Regulates Vascular Remodeling Through Encoding a Novel Protein Arteridin.

Junyi Yu, Wei Wang, Jining Yang, Ye Zhang, Xue Gong, Hao Luo, Nian Cao, Zaicheng Xu, Miao Tian, Peili Yang and 11 more

Erratum issuedOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
4.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 47 citations in OpenAlex.

  1. Article
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  8. Review
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  10. Emerging Roles of Long Non-Coding RNAs in Cardiovascular Diseases.Journal of cellular and molecular medicine · 2025
    Review
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  19. Article
  20. LncRNA-encoded peptides in cancer.Journal of hematology & oncology · 2024
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

21 authors at 6 institutions in 2 countries.

Junyi Yu *Department of Cardiology, Daping Hospital, The Third Military Medical University (Army Medical University), Chongqing, P.R. China (J. Yu, W.W., Y.Z., X.G., H.L., N.C., Z.X., M.T., P.Y., Q.M., Z.C., Z.L., C.L., G.W., C.Z.).ORCID 0000-0002-3098-1482
Wei Wang *Department of Cardiology, Daping Hospital, The Third Military Medical University (Army Medical University), Chongqing, P.R. China (J. Yu, W.W., Y.Z., X.G., H.L., N.C., Z.X., M.T., P.Y., Q.M., Z.C., Z.L., C.L., G.W., C.Z.).
Jining Yang *Research Center for Nutrition and Food Safety, Chongqing Key Laboratory of Nutrition and Food Safety, Institute of Military Preventive Medicine (J. Yang), The Third Military Medical University, Chongqing, P.R. China.
Ye Zhang *Department of Cardiology, Daping Hospital, The Third Military Medical University (Army Medical University), Chongqing, P.R. China (J. Yu, W.W., Y.Z., X.G., H.L., N.C., Z.X., M.T., P.Y., Q.M., Z.C., Z.L., C.L., G.W., C.Z.).
Xue GongDepartment of Cardiology, Daping Hospital, The Third Military Medical University (Army Medical University), Chongqing, P.R. China (J. Yu, W.W., Y.Z., X.G., H.L., N.C., Z.X., M.T., P.Y., Q.M., Z.C., Z.L., C.L., G.W., C.Z.).
Hao LuoDepartment of Cardiology, Daping Hospital, The Third Military Medical University (Army Medical University), Chongqing, P.R. China (J. Yu, W.W., Y.Z., X.G., H.L., N.C., Z.X., M.T., P.Y., Q.M., Z.C., Z.L., C.L., G.W., C.Z.).
Nian CaoDepartment of Cardiology, Daping Hospital, The Third Military Medical University (Army Medical University), Chongqing, P.R. China (J. Yu, W.W., Y.Z., X.G., H.L., N.C., Z.X., M.T., P.Y., Q.M., Z.C., Z.L., C.L., G.W., C.Z.).
Zaicheng XuDepartment of Cardiology, Daping Hospital, The Third Military Medical University (Army Medical University), Chongqing, P.R. China (J. Yu, W.W., Y.Z., X.G., H.L., N.C., Z.X., M.T., P.Y., Q.M., Z.C., Z.L., C.L., G.W., C.Z.).
Miao TianDepartment of Cardiology, Daping Hospital, The Third Military Medical University (Army Medical University), Chongqing, P.R. China (J. Yu, W.W., Y.Z., X.G., H.L., N.C., Z.X., M.T., P.Y., Q.M., Z.C., Z.L., C.L., G.W., C.Z.).
Peili YangDepartment of Cardiology, Daping Hospital, The Third Military Medical University (Army Medical University), Chongqing, P.R. China (J. Yu, W.W., Y.Z., X.G., H.L., N.C., Z.X., M.T., P.Y., Q.M., Z.C., Z.L., C.L., G.W., C.Z.).
Qiao MeiDepartment of Cardiology, Daping Hospital, The Third Military Medical University (Army Medical University), Chongqing, P.R. China (J. Yu, W.W., Y.Z., X.G., H.L., N.C., Z.X., M.T., P.Y., Q.M., Z.C., Z.L., C.L., G.W., C.Z.).
Zhi ChenDepartment of Cardiology, Daping Hospital, The Third Military Medical University (Army Medical University), Chongqing, P.R. China (J. Yu, W.W., Y.Z., X.G., H.L., N.C., Z.X., M.T., P.Y., Q.M., Z.C., Z.L., C.L., G.W., C.Z.).
Zhuxin LiDepartment of Cardiology, Daping Hospital, The Third Military Medical University (Army Medical University), Chongqing, P.R. China (J. Yu, W.W., Y.Z., X.G., H.L., N.C., Z.X., M.T., P.Y., Q.M., Z.C., Z.L., C.L., G.W., C.Z.).
Chuanwei LiDepartment of Cardiology, Daping Hospital, The Third Military Medical University (Army Medical University), Chongqing, P.R. China (J. Yu, W.W., Y.Z., X.G., H.L., N.C., Z.X., M.T., P.Y., Q.M., Z.C., Z.L., C.L., G.W., C.Z.).
Xudong DuanCardiovascular Research Center of Chongqing College, Chinese Academy of Sciences, University of Chinese Academy of Sciences (X.D., Q.R.L., C.Z.).
Qing Rex LyuCardiovascular Research Center of Chongqing College, Chinese Academy of Sciences, University of Chinese Academy of Sciences (X.D., Q.R.L., C.Z.).
Chen GaoDepartment of Pharmacology & Systems Physiology, University of Cincinnati College of Medicine, OH (C.G.).
Bing ZhangShanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai, China (B.Z.).ORCID 0000-0002-8836-7178
Yibin WangSignature Program in Cardiovascular and Metabolic Diseases, Duke-NUS School of Medicine, Singapore (Y.W.).ORCID 0000-0003-0852-0767
Gengze WuDepartment of Cardiology, Daping Hospital, The Third Military Medical University (Army Medical University), Chongqing, P.R. China (J. Yu, W.W., Y.Z., X.G., H.L., N.C., Z.X., M.T., P.Y., Q.M., Z.C., Z.L., C.L., G.W., C.Z.).ORCID 0000-0002-1992-5308
Chunyu ZengDepartment of Cardiology, Daping Hospital, The Third Military Medical University (Army Medical University), Chongqing, P.R. China (J. Yu, W.W., Y.Z., X.G., H.L., N.C., Z.X., M.T., P.Y., Q.M., Z.C., Z.L., C.L., G.W., C.Z.).ORCID 0000-0003-0173-5028
Army Medical University · CNUniversity of Chinese Academy of Sciences · CNFujian Medical University · CNShanghai Jiao Tong University · CNSignature Research (United States) · USUniversity of Cincinnati Medical Center · US

Funding

Systems Genetics Dissection of Non-alcoholic SteatohepatitisR01DK117850 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Aldons Jake Lusis · 2019 to 2026
$4.6M
A Systems Approach to Dissect Genetic Basis of Heart FailureR01HL123295 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LUSIS, ALDONS JAKE, WANG, YIBIN · 2014 to 2017
$2.6M
Novel Mechanisms of LncRNA Mediated Epigenetic Regulation in Cardiac HypertrophyR01HL143058 · NHLBI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI VONDRISKA, THOMAS M. · 2018 to 2021
$2.2M
NHLBI NIH HHS R01 HL123295NHLBI NIH HHS R01 HL143058NIDDK NIH HHS R01 DK117850
6 · The paper itself

Abstract

rationaleVascular smooth muscle cells (VSMCs) phenotype switch from contractile to proliferative phenotype is a pathological hallmark in various cardiovascular diseases. Recently, a subset of long noncoding RNAs was identified to produce functional polypeptides. However, the functional impact and regulatory mechanisms of long noncoding RNAs in VSMCs phenotype switching remain to be fully elucidated.

objectivesTo illustrate the biological function and mechanism of a VSMC-enriched long noncoding RNA and its encoded peptide in VSMC phenotype switching and vascular remodeling.

resultsWe identified a VSMC-enriched transcript encoded by a previously uncharacterized gene, which we called phenotype switching regulator (

conclusionsPSR is a VSMC-enriched gene, and its transcript IncPSR and encoded protein (arteridin) coordinately regulate transcriptional reprogramming through a shared interacting partner, YBX1. This is a previously uncharacterized regulatory circuit in VSMC phenotype switching during vascular remodeling, with lncPSR/arteridin as potential therapeutic targets for the treatment of VSMC phenotype switching-related vascular remodeling.

Indexed as

RNA, Long NoncodingAngiotensin IICell ProliferationCells, CulturedChromatinHumansMuscle, Smooth, VascularMyocytes, Smooth MusclePhenotypeTranscription FactorsVascular RemodelingAngiotensin IIChromatinRNA, Long NoncodingTranscription Factorsangiotensin IIcardiovascular diseasesphenotypeRNA, long noncodingvascular remodeling

Identifiers

PMID36134578
PMCPMC9588624
OpenAlexW4296620167

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.