ArticleAnnals of neurology2023
Regional Precuneus Cortical Hyperexcitability in Alzheimer's Disease Patients.
Article in Annals of neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06826261 (Home-based Transcranial Electrical Stimulation), which is not on this map. Cited by 39 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Home-based Transcranial Electrical Stimulation (tES) in Alzheimer's Disease
Who cites it
39 citing papers in PubMed, 3 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- Advances in gait research related to Alzheimer's disease.Frontiers in neurology · 2025Pooled it
- Pooled it
- Unlocking the Potential of Repetitive Transcranial Magnetic Stimulation in Alzheimer's Disease: A Meta-Analysis of Randomized Clinical Trials to Optimize Intervention Strategies.Journal of Alzheimer's disease : JAD · 2024Pooled it
- 40 Hz biparietal transcranial alternating current stimulation for Alzheimer's disease: a prospective study.BMC medicine · 2026Trial
- Effects of 52 weeks of precuneus rTMS in Alzheimer's disease patients: a randomized trial.Alzheimer's research & therapy · 2025Trial
- The landscape of plasma proteomic links to human organ imaging.Nature communications · 2026Article
- Distance-related functional connectivity alterations in first-episode, drug-naïve major depressive disorder: a resting-state fMRI study with atlas-based neurotransmitter correlates.BMC psychiatry · 2026Article
- State-Guided TMS-EEG for N100 Enhancement Study Based on Whole-Brain EEG Microstates.CNS neuroscience & therapeutics · 2026Article
- Clinical utility and prospective of TMS-EEG: Updated review from an international expert group.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2026Review
- Refining Detection of Subclinical Epileptiform Activity in Alzheimer's Disease: A Case-Control Study and Call for a Consensus.Annals of neurology · 2026Article
- APP family in inhibitory neurons controls inhibitory recruitment and short-term plasticity in the hippocampus.Molecular brain · 2026Article
- A functional MRI and magnetoencephalography study of the cognitive modulatory effect of transcranial direct current stimulation in early Alzheimer's disease.Frontiers in human neuroscience · 2026Article
- Multimodal non-invasive approaches for early Alzheimer's disease detection: a review of neuroelectrophysiological and neuroimaging techniques.Frontiers in psychiatry · 2026Review
- Neurophysiological signatures of default mode network dysfunction and cognitive decline in Alzheimer's disease.Science advances · 2025Article
- Dual transcranial electromagnetic stimulation of the precuneus boosts human long-term memory.eLife · 2025Article
- Differential Speed and Accuracy Trade-Off in Working Memory Retrieval and Bilateral Precuneus Between Older Men and Women.Brain and behavior · 2025Article
- Predicting response to non-invasive brain stimulation in post-stroke upper extremity motor impairment: the importance of neurophysiological and clinical biomarkers.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025Article
- Harnessing electroencephalography connectomes for cognitive and clinical neuroscience.Nature biomedical engineering · 2025Review
- The neurobiological foundation of effective repetitive transcranial magnetic brain stimulation in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Review
- Alpha rhythm and Alzheimer's disease: Has Hans Berger's dream come true?Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveNeuronal excitation/inhibition (E/I) imbalance is a potential cause of neuronal network malfunctioning in Alzheimer's disease (AD), contributing to cognitive dysfunction. Here, we used a novel approach combining transcranial magnetic stimulation (TMS) and electroencephalography (EEG) to probe cortical excitability in different brain areas known to be directly involved in AD pathology.
methodsWe performed TMS-EEG recordings targeting the left dorsolateral prefrontal cortex (l-DLPFC), the left posterior parietal cortex (l-PPC), and the precuneus (PC) in a large sample of patients with mild-to-moderate AD (n = 65) that were compared with a group of age-matched healthy controls (n = 21).
resultsWe found that patients with AD are characterized by a regional cortical hyperexcitability in the PC and, to some extent, in the frontal lobe, as measured by TMS-evoked potentials. Notably, cortical excitability assessed over the l-PPC was comparable between the 2 groups. Furthermore, we found that the individual level of PC excitability was associated with the level of cognitive impairment, as measured with Mini-Mental State Examination, and with corticospinal fluid levels of Aβ
interpretationOur data provide novel evidence that precuneus cortical hyperexcitability is a key feature of synaptic dysfunction in patients with AD. The current results point to the combined approach of TMS and EEG as a novel promising technique to measure hyperexcitability in patients with AD. This index could represent a useful biomarker to stage disease severity and evaluate response to novel therapies. ANN NEUROL 2023;93:371-383.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.