Evidence map›Paper›PMID 36134521›Full record

ArticleAnnals of neurology2023

Outcomes in the Year After First-Ever Ischemic Stroke in a Bi-Ethnic Population.

Lynda D Lisabeth, Devin L Brown, Liming Dong, Darin B Zahuranec, Madeline Kwicklis, Xu Shi, Erin Case, Melinda A Smith, Morgan Campbell, Joseph F Carrera and 1 more

Open access · hybridAbstract read
In one paragraph

Article in Annals of neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. The association of social isolation and family structure on stroke-specific quality of life in a community-based study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026
    Article
  4. Article
  5. Access to neighborhood destinations that offer opportunities for physical activity and socialization is associated with favorable post-stroke outcomes.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2026
    Article
  6. Review
  7. Article
  8. Article
  9. Racial and Ethnic Disparities in Stroke Incidence and Outcomes.Current cardiovascular risk reports · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Black Americans have worse stroke outcome compared with non-Hispanic whites.Journal of the National Medical Association · 2023
    Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Lynda D LisabethDepartment of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI.ORCID 0000-0001-5539-5933
Devin L BrownStroke Program, University of Michigan Medical School, Ann Arbor, MI.
Liming DongDepartment of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI.ORCID 0000-0003-1512-9424
Darin B ZahuranecStroke Program, University of Michigan Medical School, Ann Arbor, MI.ORCID 0000-0002-9772-2469
Madeline KwicklisDepartment of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI.
Xu ShiDepartment of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI.
Erin CaseDepartment of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI.
Melinda A SmithStroke Program, University of Michigan Medical School, Ann Arbor, MI.
Morgan CampbellCHRISTUS Spohn Hospitals, CHRISTUS Health system, Corpus Christi, TX.
Joseph F CarreraStroke Program, University of Michigan Medical School, Ann Arbor, MI.
Lewis B MorgensternDepartment of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI.ORCID 0000-0002-5787-592X
University of Michigan · USChristus Health · US

Funding

STROKE SURVEILLANCE IN A BIETHNIC COMMUNITYR01NS038916 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LISABETH, LYNDA D, MORGENSTERN, LEWIS B · 1999 to 2023
$20.9M
Sleep apnea health disparities in Mexican American stroke patientsR01NS070941 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BROWN, DEVIN L, LISABETH, LYNDA D · 2011 to 2015
$2.6M
NINDS NIH HHS R01 NS038916NINDS NIH HHS R01 NS070941
6 · The paper itself

Abstract

objectiveTo investigate stroke outcomes at 3, 6, and 12 months post-stroke overall and by ethnicity in a population-based, longitudinal study.

methodsFirst-ever ischemic strokes (2014-2019, n = 1,332) among Mexican American persons (n = 807) and non-Hispanic white persons (n = 525) were identified from the Brain Attack Surveillance in Corpus Christi Project. Data were collected from patient or proxy interviews (baseline, 3, 6, and 12 months post-stroke) and medical records, including functional (activities of daily living/instrumental activities of daily living score), neurological (National Institutes of Health Stroke Scale), cognitive (Modified Mini-Mental State Examination), and quality of life (QOL) outcomes (12-domain Stroke-specific Quality of Life scale). Outcome trajectories were analyzed using multivariable adjusted linear models, with generalized estimating equations to account for within-subject correlations; interactions between ethnicity and time were included to investigate ethnic differences in outcomes.

resultsThe median age was 67 years (interquartile range 58,78), 48.5% were women, and 60.6% were Mexican American persons. For all outcomes, significant improvement was seen between 3 and 6 months (p < 0.05 for all), with stability between 6 and 12 months. Mexican American persons had significantly worse outcomes compared with non-Hispanic white persons at all time points (3, 6, and 12 months), with the exception of the National Institutes of Health Stroke Scale, which did not differ by ethnicity at 6 and 12 months, and the average change in outcomes did not vary significantly by ethnicity.

interpretationOutcomes were at their worst at 3 months post-stroke, and ethnic disparities were already present, suggesting the need for early assessment and strategies to improve outcomes and possibly reduce disparities. ANN NEUROL 2023;93:348-356.

Indexed as

Ischemic StrokeStrokeActivities of Daily LivingAgedEthnicityFemaleHumansLongitudinal StudiesMaleMexican AmericansQuality of LifeRisk Factors

Identifiers

PMID36134521
PMCPMC9892337
OpenAlexW4296633783

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.