Evidence map›Paper›PMID 36134394›Full record

ArticleNanoscale advances2019

Anhydrous nanoprecipitation for the preparation of nanodispersions of tenofovir disoproxil fumarate in oils as candidate long-acting injectable depot formulations.

James J Hobson, Paul Curley, Alison C Savage, Amer Al-Khouja, Marco Siccardi, Charles Flexner, Caren Freel Meyers, Andrew Owen, Steve P Rannard

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanoscale advances, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

James J HobsonDepartment of Chemistry, University of Liverpool Crown Street Liverpool L69 7ZD UK srannard@liv.ac.uk.
Paul CurleyDepartment of Molecular and Clinical Pharmacology, University of Liverpool Block H, 70 Pembroke Place Liverpool L69 3GF UK.
Alison C SavageDepartment of Chemistry, University of Liverpool Crown Street Liverpool L69 7ZD UK srannard@liv.ac.uk.
Amer Al-KhoujaDepartment of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine 725 North Wolfe St. Baltimore MD 21205 USA.
Marco SiccardiDepartment of Molecular and Clinical Pharmacology, University of Liverpool Block H, 70 Pembroke Place Liverpool L69 3GF UK.
Charles FlexnerDepartment of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine 725 North Wolfe St. Baltimore MD 21205 USA.
Caren Freel MeyersDepartment of Pharmacology and Molecular Sciences, The Johns Hopkins University School of Medicine 725 North Wolfe St. Baltimore MD 21205 USA.
Andrew OwenDepartment of Molecular and Clinical Pharmacology, University of Liverpool Block H, 70 Pembroke Place Liverpool L69 3GF UK.
Steve P RannardDepartment of Chemistry, University of Liverpool Crown Street Liverpool L69 7ZD UK srannard@liv.ac.uk.ORCID https://orcid.org/0000-0002-6946-1097

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The facile formation of drug nanoparticles in injectable/ingestible oils, of water-soluble antiretroviral tenofovir disoproxil fumarate, using a novel nanoprecipitation is presented with studies showing drug release into relevant aqueous media.

Identifiers

PMID36134394
PMCPMC9417103

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.