Evidence map›Paper›PMID 36134334›Full record

ArticleiScience2022

Allograft inflammatory factor-1-like is a situational regulator of leptin levels, hyperphagia, and obesity.

Dippal Parikh, Smitha Jayakumar, Gustavo H Oliveira-Paula, Vanessa Almonte, Dario F Riascos-Bernal, Nicholas E S Sibinga

Open access · goldAbstract read
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Frontiers in nutrition · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Dippal ParikhDepartment of Medicine (Cardiology), and Department of Developmental and Molecular Biology, Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
Smitha JayakumarDepartment of Medicine (Cardiology), and Department of Developmental and Molecular Biology, Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
Gustavo H Oliveira-PaulaDepartment of Medicine (Cardiology), and Department of Developmental and Molecular Biology, Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
Vanessa AlmonteDepartment of Medicine (Cardiology), and Department of Developmental and Molecular Biology, Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
Dario F Riascos-BernalDepartment of Medicine (Cardiology), and Department of Developmental and Molecular Biology, Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
Nicholas E S SibingaDepartment of Medicine (Cardiology), and Department of Developmental and Molecular Biology, Wilf Family Cardiovascular Research Institute, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
Albert Einstein College of Medicine · US

Funding

Translational Research CoreP30DK020541 · NIDDK · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI JILL CRANDALL · 2015 to 2026
$27.7M
TRAINING PROGRAM IN CELLULAR &MOLEC. BIOLOGY &GENETICST32GM007491 · NIGMS · YESHIVA UNIVERSITY · PI QUERY, CHARLES C · 1985 to 2021
$17.0M
Metabolic control in vascular remodelingR01HL149921 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SIBINGA, NICHOLAS E · 2020 to 2023
$2.4M
Allograft inflammatory factor-1 in atherosclerosisR01HL128066 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI SIBINGA, NICHOLAS E · 2015 to 2018
$2.1M
Allograft inflammatory factor-1 and immune toleranceR21AI171739 · NIAID · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI SIBINGA, NICHOLAS E · 2022 to 2023
$462k
Role of colony stimulating factor 1 receptor (CSF1R) in graft vascular diseaseF31HL144041 · NHLBI · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI ALMONTE, VANESSA MARIA · 2018 to 2020
$129k
NHLBI NIH HHS F31 HL144041NHLBI NIH HHS R01 HL128066NHLBI NIH HHS R01 HL149921NIAID NIH HHS R21 AI171739NIDDK NIH HHS P30 DK020541NIGMS NIH HHS T32 GM007491
6 · The paper itself

Abstract

Mouse models enable the study of genetic factors affecting the complex pathophysiology of metabolic disorders. Here, we identify reductions in leptin levels, food intake, and obesity due to high-fat diet, accompanied by increased leptin sensitivity, in mice that harbor the E2a-Cre transgene within

Indexed as

Endocrine system physiologyMolecular physiologyObesity medicine

Identifiers

PMID36134334
PMCPMC9483794
OpenAlexW4294550807

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.