Evidence map›Paper›PMID 36134331›Full record

ArticleFrontiers in physiology2022

Effects of hyperventilation length on muscle sympathetic nerve activity in healthy humans simulating periodic breathing.

Jens Spiesshoefer, Alberto Giannoni, Chiara Borrelli, Paolo Sciarrone, Imke Husstedt, Michele Emdin, Claudio Passino, Florian Kahles, Tye Dawood, Binaya Regmi and 4 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Sympathetic nerve activity and response to physiological stress in Takotsubo syndrome.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2025
    Trial
  2. Autonomic effects of simulated periodic breathing in patients with chronic heart failure on contemporary guideline-directed therapy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026
    Article
  3. Effective non-invasive ventilation reduces muscle sympathetic nerve activity in patients with stable hypercapnic COPD.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 3 countries.

Jens SpiesshoeferInstitute of Life Sciences, Scuola Superiore Sant'Anna, Pisa, Italy.
Alberto GiannoniInstitute of Life Sciences, Scuola Superiore Sant'Anna, Pisa, Italy.
Chiara BorrelliInstitute of Life Sciences, Scuola Superiore Sant'Anna, Pisa, Italy.
Paolo SciarroneFondazione Toscana Gabriele Monasterio, Pisa, Italy.
Imke HusstedtDepartment of Neurology with Institute for Translational Neurology, University of Muenster, Muenster, Germany.
Michele EmdinInstitute of Life Sciences, Scuola Superiore Sant'Anna, Pisa, Italy.
Claudio PassinoInstitute of Life Sciences, Scuola Superiore Sant'Anna, Pisa, Italy.
Florian KahlesDepartment of Cardiology and Vascular Medicine, University Hospital RWTH Aachen, Aachen, Germany.
Tye DawoodHuman Autonomic Neurophysiology Laboratory, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.
Binaya RegmiDepartment of Pneumology and Intensive Care Medicine, University Hospital RWTH Aachen, Aachen, Germany.
Matthew NaughtonDepartment of Respiratory Medicine, The Alfred Hospital, Melbourne, VIC, Australia.
Michael DreherDepartment of Pneumology and Intensive Care Medicine, University Hospital RWTH Aachen, Aachen, Germany.
Matthias BoentertFondazione Toscana Gabriele Monasterio, Pisa, Italy.
Vaughan G MacefieldHuman Autonomic Neurophysiology Laboratory, Baker Heart and Diabetes Institute, Melbourne, VIC, Australia.
Fondazione Toscana Gabriele Monasterio · ITRWTH Aachen University · DEScuola Superiore Sant'Anna · ITBaker Heart and Diabetes Institute · AUThe Alfred Hospital · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

central sleep apneahyperventilationmuscle sympathetic nerve activityphysiologyrisk factor

Identifiers

PMID36134331
PMCPMC9483206
OpenAlexW4294607462

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.