ArticleNanoscale advances2021
Self-assembled anionic and cationic Au nanoparticles with Au nanoclusters for the exploration of different biological responsiveness in cancer therapy.
Article in Nanoscale advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The trial behind it
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Who cites it
4 citing papers in PubMed.
- Multifunctional gold nanoclusters as next-generation theranostic platforms for disease management.International journal of pharmaceutics: X · 2025Review
- Prospects of nanotechnology and natural products for cancer and immunotherapy.Beilstein journal of nanotechnology · 2025Review
- Divergent Responses of Hydrophilic CdSe and CdSe@CdS Core-Shell Nanocrystals in Apoptosis and In Vitro Cancer Cell Imaging: A Comparative Analysis.Journal of functional biomaterials · 2023Article
- Biomimetic Boron Nitride Nanoparticles for Targeted Drug Delivery and Enhanced Antitumor Activity.Pharmaceutics · 2023Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Self-assembly overcomes the biodegradation resistance of some traditional inorganic drug carriers. Herein, we prepared self-assembled Au nanocluster-based nanoparticles with different sizes and charges based on solvent- and cation-induced self-assembly nanotechnology as anti-cancer drug vehicles to solve the potential metabolism problems of solid gold nanoparticles. We also systematically explored the responsiveness of cancer cells to self-assembled Au nanocluster-based nanoparticles with different sizes and surface modified properties. We discovered that self-assembled nanoparticles inherited molecular-like properties of small-size Au NCs and exhibited an aggregation-induced emission (AIE) phenomenon with intense luminescence. Self-assembled Au nanocluster-based nanoparticles (Au NPs and cAu NPs) taking advantage of their size and positive charge exhibited better cell uptake than Au NCs. Encouraged by the excellent biological compatibility and cell uptake of these nanomaterials, we prepared drug-loaded nanomaterials by diffusion absorption and hydrophobic-induced embedding. cAu NPs@DOX showed an excellent anti-cancer effect owing to efficient cell internalization; Au NPs@DOX exhibited slow release of cargo drugs which might be significant to
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Registered trials
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