Evidence map›Paper›PMID 36134165›Full record

ArticleNanoscale advances2021

Trafficking of JC virus-like particles across the blood-brain barrier.

Dong Ye, Tina Zimmermann, Victoria Demina, Sergey Sotnikov, Christian L Ried, Harri Rahn, Marcus Stapf, Christopher Untucht, Michael Rohe, Georg C Terstappen and 4 more

Open access · goldAbstract read
In one paragraph

Article in Nanoscale advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.3field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

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  11. Virus-like Particles for TEM Regulation and Antitumor Therapy.Journal of functional biomaterials · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Dong YeAbbVie Deutschland GmbH & Co. KG, DMPK, Bioanalytical Research Knollstraße 67061 Ludwigshafen Germany dong.ye@abbvie.com axel.meyer@abbvie.com.
Tina ZimmermannAbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery Knollstraße 67061 Ludwigshafen Germany.
Victoria DeminaNEUWAY Pharma GmbH Ludwig-Erhard-Allee 2 53175 Bonn Germany.
Sergey SotnikovNEUWAY Pharma GmbH Ludwig-Erhard-Allee 2 53175 Bonn Germany.
Christian L RiedAbbVie Deutschland GmbH & Co. KG, Development Sciences NBE Knollstraße 67061 Ludwigshafen Germany.
Harri RahnAbbVie Deutschland GmbH & Co. KG, Development Sciences NBE Knollstraße 67061 Ludwigshafen Germany.
Marcus StapfNEUWAY Pharma GmbH Ludwig-Erhard-Allee 2 53175 Bonn Germany.
Christopher UntuchtAbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery Knollstraße 67061 Ludwigshafen Germany.
Michael RoheAbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery Knollstraße 67061 Ludwigshafen Germany.
Georg C TerstappenAbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery Knollstraße 67061 Ludwigshafen Germany.
Karsten WickeAbbVie Deutschland GmbH & Co. KG, Neuroscience Discovery Knollstraße 67061 Ludwigshafen Germany.
Mario MezlerAbbVie Deutschland GmbH & Co. KG, DMPK, Bioanalytical Research Knollstraße 67061 Ludwigshafen Germany dong.ye@abbvie.com axel.meyer@abbvie.com.
Heiko ManningaNEUWAY Pharma GmbH Ludwig-Erhard-Allee 2 53175 Bonn Germany.
Axel H MeyerAbbVie Deutschland GmbH & Co. KG, DMPK, Bioanalytical Research Knollstraße 67061 Ludwigshafen Germany dong.ye@abbvie.com axel.meyer@abbvie.com.ORCID https://orcid.org/0000-0001-7180-0847
Ludwigshafen University of Business and Society · DEUniversity of Bonn · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hollow viral vectors, such as John Cunningham virus-like particles (JC VLPs), provide a unique opportunity to deliver drug cargo into targeted cells and tissue. Current understanding of the entry of JC virus in brain cells has remained insufficient. In particular, interaction of JC VLPs with the blood-brain barrier (BBB) has not been analyzed in detail. Thus, JC VLPs were produced in this study for investigating the trafficking across the BBB. We performed a carotid artery injection procedure for mouse brain to qualitatively study JC VLPs'

Identifiers

PMID36134165
PMCPMC9418390
OpenAlexW3126409999

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.