Evidence map›Paper›PMID 36133793›Full record

ArticleMaterials today. Bio2022

Poly(2-alkyl-2-oxazoline)s: A polymer platform to sustain the release from tablets with a high drug loading.

Aseel Samaro, Maarten Vergaelen, Martin Purino, Ali Tigrine, Victor R de la Rosa, Niloofar Moazami Goudarzi, Matthieu N Boone, Valérie Vanhoorne, Richard Hoogenboom, Chris Vervaet

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Aseel SamaroLaboratory of Pharmaceutical Technology, Ghent University, Ottergemsesteenweg, 460 9000, Ghent, Belgium.
Maarten VergaelenSupramolecular Chemistry Group, Centre of Macromolecular Chemistry (CMaC), Department of Organic and Macromolecular Chemistry, Krijgslaan 281-S4 9000 Ghent University, Ghent, Belgium.
Martin PurinoSupramolecular Chemistry Group, Centre of Macromolecular Chemistry (CMaC), Department of Organic and Macromolecular Chemistry, Krijgslaan 281-S4 9000 Ghent University, Ghent, Belgium.
Ali TigrineSupramolecular Chemistry Group, Centre of Macromolecular Chemistry (CMaC), Department of Organic and Macromolecular Chemistry, Krijgslaan 281-S4 9000 Ghent University, Ghent, Belgium.
Victor R de la RosaSupramolecular Chemistry Group, Centre of Macromolecular Chemistry (CMaC), Department of Organic and Macromolecular Chemistry, Krijgslaan 281-S4 9000 Ghent University, Ghent, Belgium.
Niloofar Moazami GoudarziRadiation Physics Research Group, Department of Physics and Astronomy, Ghent University, Belgium.
Matthieu N BooneRadiation Physics Research Group, Department of Physics and Astronomy, Ghent University, Belgium.
Valérie VanhoorneLaboratory of Pharmaceutical Technology, Ghent University, Ottergemsesteenweg, 460 9000, Ghent, Belgium.
Richard HoogenboomSupramolecular Chemistry Group, Centre of Macromolecular Chemistry (CMaC), Department of Organic and Macromolecular Chemistry, Krijgslaan 281-S4 9000 Ghent University, Ghent, Belgium.
Chris VervaetLaboratory of Pharmaceutical Technology, Ghent University, Ottergemsesteenweg, 460 9000, Ghent, Belgium.
Ghent University · BEAblynx (Belgium) · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sustaining the release of highly dosed APIs from a matrix tablet is challenging. To address this challenge, this study evaluated the performance of thermoplastic poly (2-alkyl-2-oxazoline)s (PAOx) as matrix excipient to produce sustained-release tablets via three processing routes: (a) hot-melt extrusion (HME) combined with injection molding (IM), (b) HME combined with milling and compression and (c) direct compression (DC). Different PAOx (co-)polymers and polymer mixtures were processed with several active pharmaceutical ingredients having different aqueous solubilities and melting temperatures (metoprolol tartrate (MPT), metformin hydrochloride (MTF) and theophylline anhydrous (THA)). Different PAOx grades were synthesized and purified by the Supramolecular Chemistry Group, and the effect of PAOx grade and processing technique on the

Indexed as

Alkyl side chainDirect compressionHot-melt extrusionInjection moldingIn vivoPoly(2-alkyl-2-oxazoline)sSustained-release

Identifiers

PMID36133793
PMCPMC9483731
OpenAlexW4295290169

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.