Evidence map›Paper›PMID 36133743›Full record

ArticleMediators of inflammation2022

Knockdown of LMX1B Suppressed Cell Apoptosis and Inflammatory Response in IL-1

Yiping Mu, Lining Wang, Ling Fu, Qi Li

Open access · goldAbstract read
In one paragraph

Article in Mediators of inflammation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.9field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
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  7. Article
  8. Genetic polymorphisms ofBiomarkers in medicine · 2024
    Article
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  10. Article
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  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yiping MuHand Surgery Department, Central Hospital Affiliated to Shenyang Medical Collage, Shenyang Clinical Research for Hand and Foot Diseases, Shenyang, 110024 Liaoning Province, China.ORCID https://orcid.org/0000-0002-9200-4556
Lining WangLaboratory Department, Central Hospital Affiliated to Shenyang Medical College, Shenyang, 110024 Liaoning Province, China.ORCID https://orcid.org/0000-0002-5443-0247
Ling FuHand Surgery Department, Central Hospital Affiliated to Shenyang Medical Collage, Shenyang Clinical Research for Hand and Foot Diseases, Shenyang, 110024 Liaoning Province, China.
Qi LiHand Surgery Department, Central Hospital Affiliated to Shenyang Medical Collage, Shenyang Clinical Research for Hand and Foot Diseases, Shenyang, 110024 Liaoning Province, China.ORCID https://orcid.org/0000-0002-4740-8295
Central Hospital Affiliated to Shenyang Medical College · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoarthritis (OA), a chronic degenerative joint disease, always occurred in the aging population. There is evidence suggests that chondrocytes' survival, inflammation, and apoptosis play critical roles in OA pathogenesis. LMX1B has been shown to be involved in antiosteogenic function in early patterning of the calvaria. However, the role and mechanism of LMX1B in OA is not unknown. The present study observed that LMX1B was highly expressed in OA patients compared with normal patients. Besides, we found that IL-1

Indexed as

ChondrocytesOsteoarthritisAgedAnimalsApoptosisCells, CulturedDinoprostoneHumansInflammationInterleukin-1betaInterleukin-6LIM-Homeodomain ProteinsMatrix Metalloproteinase 13Matrix Metalloproteinase 3NF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinDinoprostoneInterleukin-1betaInterleukin-6LIM homeobox transcription factor 1 betaLIM-Homeodomain ProteinsMatrix Metalloproteinase 13Matrix Metalloproteinase 3NF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, ratRNA, MessengerTranscription FactorsTumor Necrosis Factor-alpha

Identifiers

PMID36133743
PMCPMC9484960
OpenAlexW4296580007

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.