Evidence map›Paper›PMID 36133355›Full record

ArticleTranslational research in anatomy2022

Extended reality visualization of medical museum specimens: Online presentation of conjoined twins curated by Dr. Jacob Henle between 1844-1852.

Brandi S Mikami, Thomas E Hynd, U-Young Lee, J DeMeo, Jesse D Thompson, Roman Sokiranski, Sara Doll, Scott Lozanoff

Open access · goldAbstract read
In one paragraph

Article in Translational research in anatomy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. The history of anatomical engagement.Anatomical sciences education · 2025
    Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 4 countries.

Brandi S MikamiDepartment of Anatomy, Biochemistry & Physiology, John A. Burns School of Medicine, Honolulu, HI, 96813, USA.
Thomas E HyndDepartment of Biology, James Madison University, Harrisonburg, VA, 22807, USA.
U-Young LeeDepartment of Anatomy, Biochemistry & Physiology, John A. Burns School of Medicine, Honolulu, HI, 96813, USA.
J DeMeoDepartment of Anatomy, Biochemistry & Physiology, John A. Burns School of Medicine, Honolulu, HI, 96813, USA.
Jesse D ThompsonDepartment of Anatomy, Biochemistry & Physiology, John A. Burns School of Medicine, Honolulu, HI, 96813, USA.
Roman SokiranskiDepartment of Anatomy & Cell Biology, Medical University of Varna, Varna, BG-9002, Bulgaria.
Sara DollDepartment of Anatomy and Cell Biology, University of Heidelberg, Heidelberg, DE, 69120, USA.
Scott LozanoffDepartment of Anatomy, Biochemistry & Physiology, John A. Burns School of Medicine, Honolulu, HI, 96813, USA.
University of Hawaiʻi at Mānoa · USHeidelberg University · DEJames Madison University · USMedical University of Varna · BG

Funding

UH Hilo COP A&RP20GM103466 · NIGMS · UNIVERSITY OF HAWAII AT MANOA · PI HELEN C TURNER · 2012 to 2026
$60.3M
NIGMS NIH HHS P20 GM103466
6 · The paper itself

Abstract

Background: The purpose of this study is to characterize a full-term conjoined twins' cadaver curated by Dr. Jacob Henle sometime between 1844 and 1852 and demonstrate digital distribution of an old and rare medical museum specimen using an extended reality (XR) model workflow. Methods: The cadaver (Preparation 296) is in the Department of Anatomy and Cell Biology at the University of Heidelberg. An XR display workflow comprises image capture, segmentation, and visualization using CT/MR scans derived from the cadaver. Online radiology presentation to medical students focuses on diagnostic characteristics of anatomical systems depicted with XR models. Results: Developmental defects in Preparation 296 include duplicated supradiaphragmatic structures and abnormal osteological features. Subdiaphragmatically, the gut is continuous on the right, but terminates at the distal esophagus on the left. One large liver occupies the abdomen with one spleen located on the left side. Observations suggest duplication of the primitive streak and separate notochords rostrally. Duplication occurs near the yolk sac and involves midgut formation while secondary midline fusion of the upper extremities and ribs likely results from the proximity of the embryos during development. Medical students access the model with device agnostic software during the curricular topic "Human Body Plan" that includes embryology concepts covering mechanisms of twinning. Conclusions: The workflow enables ease-of-access XR visualizations of an old and rare museum specimen. This study also demonstrates digital distribution and utilization of XR models applicable to embryology education.

Indexed as

Conjoined twinsJacob henleMedical museum specimensXR anatomy

Identifiers

PMID36133355
PMCPMC9489256
OpenAlexW4212911312

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.