Evidence map›Paper›PMID 36132778›Full record

ArticleNanoscale advances2020

Poly-d-lysine coated nanoparticles to identify pro-inflammatory macrophages.

Derek S Hernandez, Hattie C Schunk, Karan M Shankar, Adrianne M Rosales, Laura J Suggs

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanoscale advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Oxidative Degradation of Sequence-Defined Peptoid Oligomers.Molecular systems design & engineering · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Derek S HernandezDepartment of Biomedical Engineering, University of Texas at Austin Austin TX 78712 USA suggs@utexas.edu.
Hattie C SchunkDepartment of Biomedical Engineering, University of Texas at Austin Austin TX 78712 USA suggs@utexas.edu.ORCID https://orcid.org/0000-0002-4768-2569
Karan M ShankarDepartment of Biomedical Engineering, University of Texas at Austin Austin TX 78712 USA suggs@utexas.edu.
Adrianne M RosalesMcKetta Department of Chemical Engineering, University of Texas at Austin Austin TX 78712 USA.ORCID https://orcid.org/0000-0003-0207-7661
Laura J SuggsDepartment of Biomedical Engineering, University of Texas at Austin Austin TX 78712 USA suggs@utexas.edu.ORCID https://orcid.org/0000-0002-1419-8017

Funding

Nanotracer Development to Track Stem Cell TherapyR01EB015007 · NIBIB · UNIVERSITY OF TEXAS AT AUSTIN · PI SUGGS, LAURA J · 2012 to 2020
$3.7M
NIBIB NIH HHS R01 EB015007
6 · The paper itself

Abstract

Identifying pro-inflammatory macrophages (M1) is of immense importance to diagnose, monitor, and treat various pathologies. In addition, adoptive cell therapies, where harvested cells are isolated, modified to express an M1-like phenotype, then re-implanted to the patient, are also becoming more prevalent to treat diseases such as cancer. In a step toward identifying, labeling, and monitoring macrophage phenotype for adoptive cell therapies, we developed a reactive oxygen species (ROS)-sensitive, gold nanoparticle (AuNP) that fluorescently labels M1 macrophages. AuNPs are electrostatically coated with a proteolysis resistant, fluorescein isothiocyanate-conjugated, poly-d-lysine (PDL-FITC) that is susceptible to backbone cleavage by ROS. When PDL-FITC is bound to AuNPs, fluorescence is quenched

Identifiers

PMID36132778
PMCPMC9416964

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.