Evidence map›Paper›PMID 36132776›Full record

ArticleNanoscale advances2020

Biokinetics and clearance of inhaled gold ultrasmall-in-nano architectures.

Ana Katrina Mapanao, Giulia Giannone, Maria Summa, Maria Laura Ermini, Agata Zamborlin, Melissa Santi, Domenico Cassano, Rosalia Bertorelli, Valerio Voliani

Abstract read
In one paragraph

Article in Nanoscale advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Ultrasmall-in-Nano: Why Size Matters.Nanomaterials (Basel, Switzerland) · 2022
    Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. A Standard Protocol for the Production and Bioevaluation of EthicalACS pharmacology & translational science · 2021
    Article
  15. Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ana Katrina MapanaoCenter for Nanotechnology Innovation@NEST, Istituto Italiano di Tecnologia Piazza San Silvestro 12 - 56127 Pisa Italy valerio.voliani@iit.it.
Giulia GiannoneCenter for Nanotechnology Innovation@NEST, Istituto Italiano di Tecnologia Piazza San Silvestro 12 - 56127 Pisa Italy valerio.voliani@iit.it.
Maria SummaTranslational Pharmacology, Istituto Italiano di Tecnologia Via Morego 30 - 16163 Genoa Italy.
Maria Laura ErminiCenter for Nanotechnology Innovation@NEST, Istituto Italiano di Tecnologia Piazza San Silvestro 12 - 56127 Pisa Italy valerio.voliani@iit.it.
Agata ZamborlinCenter for Nanotechnology Innovation@NEST, Istituto Italiano di Tecnologia Piazza San Silvestro 12 - 56127 Pisa Italy valerio.voliani@iit.it.
Melissa SantiCenter for Nanotechnology Innovation@NEST, Istituto Italiano di Tecnologia Piazza San Silvestro 12 - 56127 Pisa Italy valerio.voliani@iit.it.
Domenico CassanoCenter for Nanotechnology Innovation@NEST, Istituto Italiano di Tecnologia Piazza San Silvestro 12 - 56127 Pisa Italy valerio.voliani@iit.it.
Rosalia BertorelliTranslational Pharmacology, Istituto Italiano di Tecnologia Via Morego 30 - 16163 Genoa Italy.
Valerio VolianiCenter for Nanotechnology Innovation@NEST, Istituto Italiano di Tecnologia Piazza San Silvestro 12 - 56127 Pisa Italy valerio.voliani@iit.it.ORCID https://orcid.org/0000-0003-1311-3349

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Among an organism's entry portals, the respiratory tract is one of the most promising routes for non-invasive administration of therapeutics for local and systemic delivery. On the other hand, it is the subtlest to protect from environmental pollution and microbial occurrences. Here, the biokinetics, distribution, and clearance trends of gold ultrasmall-in-nano architectures administered through a single intranasal application have been quantitatively evaluated. Apart from reaching the lung parenchyma, the (bio)degradable nano-architectures are able to translocate as well to secondary organs and be almost completely excreted within 10 days. These findings further support the clinical relevance of plasmonic nanomaterials for oncology and infectious disease treatment and management. Notably, this investigation also provides crucial information regarding the associated risks as a consequence of the pulmonary delivery of nanoparticles.

Identifiers

PMID36132776
PMCPMC9417912

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.