Evidence map›Paper›PMID 36132649›Full record

ArticleNanoscale advances2021

The role of size and nature in nanoparticle binding to a model lung membrane: an atomistic study.

Ankush Singhal, G J Agur Sevink

Abstract read
In one paragraph

Article in Nanoscale advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
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  4. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ankush SinghalLeiden Institute of Chemistry, Leiden University P.O. Box 9502 2300 RA Leiden The Netherlands a.singhal@lic.leidenuniv.nl a.sevink@lic.leidenuniv.nl.ORCID https://orcid.org/0000-0003-2949-6962
G J Agur SevinkLeiden Institute of Chemistry, Leiden University P.O. Box 9502 2300 RA Leiden The Netherlands a.singhal@lic.leidenuniv.nl a.sevink@lic.leidenuniv.nl.ORCID https://orcid.org/0000-0001-8005-0697

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Understanding the uptake of nanoparticles (NPs) by different types of cellular membranes plays a pivotal role in the design of NPs for medical applications and in avoiding adverse effects that result in nanotoxicity. Yet, the role of key design parameters, such as the bare NP material, NP size and surface reactivity, and the nature of NP coatings, in membrane remodelling and uptake mechanisms is still very poorly understood, particularly towards the lower range of NP dimensions that are beyond the experimental imaging resolution. The same can be said about the role of a particular membrane composition. Here, we systematically employ biased and unbiased molecular dynamics simulations to calculate the binding energy for three bare materials (Ag/SiO

Identifiers

PMID36132649
PMCPMC9417560

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.