Evidence map›Paper›PMID 36132527›Full record

ArticleNanoscale advances2020

A nano-integrated diagnostic and therapeutic platform with oxidation-reduction reactions in tumor microenvironments.

Lei Zhao, Guihua Qiu, Kai Wang, Hu Chen, Fengkai Ruan, Nan Liu, Zifeng Deng, Youliang Yao, Dongbei Guo, Dai Wang and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanoscale advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Lei ZhaoState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University Xiamen Fujian 361102 PR China z63y94x@xmu.edu.cn.
Guihua QiuState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University Xiamen Fujian 361102 PR China z63y94x@xmu.edu.cn.
Kai WangState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University Xiamen Fujian 361102 PR China z63y94x@xmu.edu.cn.
Hu ChenState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University Xiamen Fujian 361102 PR China z63y94x@xmu.edu.cn.
Fengkai RuanState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University Xiamen Fujian 361102 PR China z63y94x@xmu.edu.cn.
Nan LiuState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University Xiamen Fujian 361102 PR China z63y94x@xmu.edu.cn.
Zifeng DengState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University Xiamen Fujian 361102 PR China z63y94x@xmu.edu.cn.
Youliang YaoState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University Xiamen Fujian 361102 PR China z63y94x@xmu.edu.cn.
Dongbei GuoState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University Xiamen Fujian 361102 PR China z63y94x@xmu.edu.cn.
Dai WangState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University Xiamen Fujian 361102 PR China z63y94x@xmu.edu.cn.
Li ShaAffiliated Zhongshan Hospital of Dalian University Dalian Liaoning 116001 PR China liuwenzhi196507@163.com.
Xiangyu KongAffiliated Zhongshan Hospital of Dalian University Dalian Liaoning 116001 PR China liuwenzhi196507@163.com.
Wenzhi LiuAffiliated Zhongshan Hospital of Dalian University Dalian Liaoning 116001 PR China liuwenzhi196507@163.com.
Yongxing ZhangState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University Xiamen Fujian 361102 PR China z63y94x@xmu.edu.cn.ORCID https://orcid.org/0000-0001-8823-2487
Xiamen University · CNAffiliated Zhongshan Hospital of Dalian University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In the present study, we developed a nano-integrated diagnostic and therapeutic platform with oxidation-reduction reactions in tumor microenvironments (TMEs). The proposed platform resolved the contradiction of particle size between the enhanced permeability and retention (EPR) effect and tumor interstitial penetration, as well as poor circulation and low drug-loading efficiency. Flower-like MnO

Identifiers

PMID36132527
PMCPMC9418791
OpenAlexW3012386088

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.