ArticleNanoscale advances2020
Bio-electrostatic sensitive droplet lasers for molecular detection.
Article in Nanoscale advances, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The trial behind it
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Who cites it
11 citing papers in PubMed.
- Membrane Proteins in Action Monitored by pH-Responsive Liquid Crystal Biosensors.ACS applied materials & interfaces · 2024Article
- Label-free, ultra-low detection limit DNA biosensor using high quality optical microcavity functionalized by DNA tetrahedral nanostructure probes.Nanophotonics (Berlin, Germany) · 2023Article
- Recent Development of Tunable Optical Devices Based on Liquid.Molecules (Basel, Switzerland) · 2022Review
- A systemic review on liquid crystals, nanoformulations and its application for detection and treatment of SARS - CoV- 2 (COVID - 19).Journal of molecular liquids · 2022Review
- Review
- Liquid Crystal Biosensors: Principles, Structure and Applications.Biosensors · 2022Review
- Monitoring Various Bioactivities at the Molecular, Cellular, Tissue, and Organism Levels via Biological Lasers.Sensors (Basel, Switzerland) · 2022Review
- Droplet Lasers for Smart Photonic Labels.ACS applied materials & interfaces · 2021Article
- Topological Encoded Vector Beams for Monitoring Amyloid-Lipid Interactions in Microcavity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Review of biosensing with whispering-gallery mode lasers.Light, science & applications · 2021Review
- Liquid crystal-amplified optofluidic biosensor for ultra-highly sensitive and stable protein assay.PhotoniX · 2021Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Electrostatics plays a critical function in most biomolecules, therefore monitoring molecular electrostatic interactions at the biointerface can provide the basis in diagnosis and biomedical science. Herein we report a bioelectrostatic responsive microlaser based on liquid crystal (LC) droplets and explored its application for the ultrasensitive detection of negatively charged biomolecules. A whispering gallery mode (WGM) laser from positively charged LC microdroplets was designed as the optical resonator, in which the lasing wavelength shift was employed as the sensing parameter. We verified that molecular electrostatic changes at the biointerface of the droplet trigger a wavelength shift in laser spectra. Compared to a conventional polarized optical microscope, a significantly improved sensitivity and dynamic range by four orders of magnitude were achieved. Our results helped discover that the surface-to-volume ratio plays a critical role in the detection sensitivity in WGM laser-based microsensors. Finally, bovine serum albumin and specific biosensing were exploited to demonstrate the potential applications of microlasers with a detection limit in the order of 1 pM, thus offering new alternatives for ultrasensitive label-free biosensing and monitoring of molecular interactions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.