ArticleNanoscale advances2021
Multifunctional carbon dots with near-infrared absorption and emission for targeted delivery of anticancer drugs, tumor tissue imaging and chemo/photothermal synergistic therapy.
Article in Nanoscale advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 34 citations in OpenAlex.
- Review
- Carbon nanodots as theranostics agents in cancer: advances in design, targeting, and real-time monitoring.RSC advances · 2026Review
- Synthesis of biomass nitrogen self-doped carbon quantum dots and their application in multicolor imaging and temperature sensing in cells.Mikrochimica acta · 2026Article
- Synthesis of corn-derived carbon quantum dots and their application in intracellular pH sensing and multicolor cellular imaging.iScience · 2025Article
- Harnessing Lignin-Derived Carbon Dots for Enhanced NIR Photothermal Ablation of Melanoma Cells.ACS omega · 2025Article
- Green synthesis of near-infrared carbon dots as a novel aptamer-based fluorescence probe for the detection and imaging of alpha-fetoprotein.Mikrochimica acta · 2025Article
- Preparation of biomass-derived red emission carbon dots for real-time and long-term tracking of cells and tumor growth.RSC advances · 2024Article
- Tumor-Targeted cRGD-Coated Liposomes Encapsulating Optimized Synergistic Cepharanthine and IR783 for Chemotherapy and Photothermal Therapy.International journal of nanomedicine · 2024Article
- Red emitting carbon dots: surface modifications and bioapplications.Nanoscale advances · 2023Review
- Enhancing catalytic efficiency of carbon dots by modulating their Mn doping and chemical structure with metal salts.RSC advances · 2023Article
- Carbon dots for photothermal applications.Frontiers in chemistry · 2022Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cancer therapy faces considerable challenges related to improving treatment efficiency and overcoming damage to healthy cells. To address these concerns, a strategy for tumor microenvironment-induced cancer imaging/drug release and synergistic chemo-photothermal therapy (chemo/PTT) is proposed in this study. Carbon dots with near-infrared (NIR) absorption and emission, referred to as RCDs, were first prepared and covalently coupled with a Pt(iv) prodrug to form a complex, referred to as RCD-Pt(iv). The surface of the prepared complex was then coated with the polyethylene glycol-chitosan-2,3-dimethylmaleic anhydride polymer (PEG-CS-DA) to obtain a tumor-targeted multifunctional nanoprobe (RCD-Pt(iv)/PEG-CS-DA). When the nanoprobe RCD-Pt(iv)/PEG-CS-DA entered the tumor cells, the acidic environment of the tumor cells allowed rapid PEG-CS-DA hydrolysis and RCD-Pt(iv) release. High levels of glutathione (GSH) in cancer cells reduced Pt(iv) to Pt(ii) and released the RCDs, resulting in cancer tissue imaging and targeted Pt(ii) release. Meanwhile, Pt(ii) collected in the tumor tissues could realize targeted chemotherapy, and the RCDs in the tumor tissues absorbed light energy under NIR light irradiation to produce a large amount of heat to quickly eliminate cancer cells. Thus, cancer tissue imaging/targeted drug release and synergistic chemo/PTT were achieved simultaneously.
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Registered trials
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