Evidence map›Paper›PMID 36132230›Full record

ArticleOxidative medicine and cellular longevity2022

4,7-Didehydro-neophysalin B Protects Rat Lung Epithelial Cells against Hydrogen Peroxide-Induced Oxidative Damage through Nrf2-Mediated Signaling Pathway.

Qiu Zhong, Yaogui Sun, Ajab Khan, Jianhua Guo, Zhirui Wang, Na Sun, Hongquan Li

Open access · hybridAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Qiu ZhongShanxi Key Lab. for Modernization of TCVM, College of Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801 Shanxi, China.
Yaogui SunShanxi Key Lab. for Modernization of TCVM, College of Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801 Shanxi, China.
Ajab KhanDepartment of Veterinary Pathology, Faculty of Veterinary and Animal Sciences, The University of Agriculture, Dera Ismail Khan 29050, Khyber Pakhtunkhwa, Pakistan.
Jianhua GuoUSA Texas A&M University, College Station, TX, USA 77843.
Zhirui WangUniversity of Colorado Denver Anschutz Medical Campus, RC2-6013, Mail Stop 8621 12700 E 19th Ave., Aurora, CO 80045, USA.
Na SunShanxi Key Lab. for Modernization of TCVM, College of Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801 Shanxi, China.
Hongquan LiShanxi Key Lab. for Modernization of TCVM, College of Veterinary Medicine, Shanxi Agricultural University, Taigu, 030801 Shanxi, China.ORCID https://orcid.org/0000-0002-2030-5587
Shanxi Agricultural University · CNTexas A&M University · USThe University of Agriculture, Peshawar · PKUniversity of Colorado Anschutz Medical Campus · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The administration of 4,7-didehydro-neophysalin B is expected to be a promising strategy for mitigating oxidative stress in respiratory diseases. This study was aimed at investigating the efficacy of 4,7-didehydro-neophysalin B for apoptosis resistance of rat lung epithelial cells (RLE-6TN) to oxidative stress and evaluating its underlying mechanism of action. The RLE-6TN cells treated with hydrogen peroxide (H

Indexed as

Hydrogen PeroxideNF-E2-Related Factor 2AnimalsAntioxidantsApoptosisbcl-2-Associated X ProteinEpithelial CellsHeme Oxygenase-1LungOxidative StressProto-Oncogene Proteins c-bcl-2RatsSignal TransductionTumor Suppressor Protein p53Antioxidantsbcl-2-Associated X ProteinHeme Oxygenase-1Hydrogen PeroxideNF-E2-Related Factor 2Proto-Oncogene Proteins c-bcl-2Tumor Suppressor Protein p53

Identifiers

PMID36132230
PMCPMC9484967
OpenAlexW4295880284

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.