Evidence map›Paper›PMID 36132081›Full record

ReviewBioMed research international2022

Harnessing the Therapeutic Potential of Exosomes: A Novel Strategy for Anticancer and Antiviral Therapy.

Njinju Asaba Clinton, Nkembi-Leke Joshua Ageboh, Baie Decler Nkache, Ebamu Sylvia Mencha, Asonganyi Aminkeng, Ewalu Justa Ndobegang, Esembieng Mencha Ivo, Simaa Rene Vigha, Cyril Jabea Ekabe

Open access · hybridAbstract readReview
In one paragraph

Review in BioMed research international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

Njinju Asaba ClintonGrace Community Health and Development Association, P. O. Box, 15 Kumba, Southwest Region, Cameroon.ORCID https://orcid.org/0000-0002-8371-9138
Nkembi-Leke Joshua AgebohFaculty of Health Sciences, University of Buea, Cameroon.ORCID https://orcid.org/0000-0001-5744-2406
Baie Decler NkacheFaculty of Health Sciences, University of Buea, Cameroon.ORCID https://orcid.org/0000-0002-1204-4129
Ebamu Sylvia MenchaFaculty of Health Sciences, University of Buea, Cameroon.ORCID https://orcid.org/0000-0002-2172-7343
Asonganyi AminkengFaculty of Health Sciences, University of Buea, Cameroon.ORCID https://orcid.org/0000-0002-9527-1916
Ewalu Justa NdobegangFaculty of Health Sciences, University of Buea, Cameroon.ORCID https://orcid.org/0000-0002-9321-8433
Esembieng Mencha IvoFaculty of Health Sciences, University of Buea, Cameroon.ORCID https://orcid.org/0000-0001-6783-0728
Simaa Rene VighaFaculty of Health Sciences, University of Buea, Cameroon.ORCID https://orcid.org/0000-0002-1100-6016
Cyril Jabea EkabeGrace Community Health and Development Association, P. O. Box, 15 Kumba, Southwest Region, Cameroon.ORCID https://orcid.org/0000-0001-6910-3719
University of Buea · CM

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Exosomes are extracellular membrane bound vesicles released from almost all cell types and can be retrieved from all body fluids. The molecular constituents of these extracellular bodies vary depending on their cell of origin, from which they can transport molecules such as DNA, RNA, proteins lipids, and several metabolites. They have been shown to execute several functions such as in cell growth, migration, differentiation, neuronal signaling, immune cell modulation, and some diseases such as cancer through intercellular communication and signaling. They are also described to act as key players in viral persistence and dissemination. Due to their ability to elicit potent cellular responses, high level of tolerance in host cells, and high efficiency in penetrating other cells, they are proposed to be potential therapeutics as well as vehicles for drug delivery. In recent years, several studies have been conducted in quest for the development of an effective anticancer therapy or antiviral therapy against highly persistent viruses. However, most of these studies become halted due to failure to achieve desired therapeutic outcomes. Nevertheless, the

Indexed as

ExosomesExtracellular VesiclesNeoplasmsAntiviral AgentsHumansLipidsProspective StudiesRNAAntiviral AgentsLipidsRNA

Identifiers

PMID36132081
PMCPMC9484893
OpenAlexW4296580116

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.